DegronMD

Uniprot ID: A0AVK6

Source protein: Transcription factor E2F8

Source gene: E2F8

Class: DEG_APCC_KENBOX_2

Location: 374:378

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9637

ASA_SCORE: 77.12

COIL: 0.416

CONS_SCORE: 0.3316

DSS_SCORE: 0.4557

HELIX: 0.5542

FCONS_SCORE: 1.1258

RIG_SCORE: 0.7198

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N381H	TCGA-A6-3808	COAD	TCGA	SKENC	DEG_APCC_KENBOX_2	0.25
p.N381H	DO8408	COAD	ICGC	SKENC	DEG_APCC_KENBOX_2	0.25
p.R372L	TCGA-A8-A09Z	BRCA	TCGA	SKENC	DEG_APCC_KENBOX_2	0.2778
p.R372L	DO5521	BRCA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.2778
p.R372L	DO233261	GACA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.2778
p.R386C	TCGA-AX-A1CE	UCEC	TCGA	SKENC	DEG_APCC_KENBOX_2	0.1111
p.R386C	DO42280	UCEC	ICGC	SKENC	DEG_APCC_KENBOX_2	0.1111
p.R386C	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	SKENC	DEG_APCC_KENBOX_2	0.1111
p.G387W	TCGA-D9-A1JX	SKCM	TCGA	SKENC	DEG_APCC_KENBOX_2	0.0833
p.G387W	DO37711	SKCM	ICGC	SKENC	DEG_APCC_KENBOX_2	0.0833
p.S384F	TCGA-FS-A4F0	SKCM	TCGA	SKENC	DEG_APCC_KENBOX_2	0.1667
p.S384F	DO37891	SKCM	ICGC	SKENC	DEG_APCC_KENBOX_2	0.1667
p.T385A	DO222492	COCA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.1389
p.K380N	DO50904	LICA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons