DegronMD

Uniprot ID: Q07699

Source protein: Sodium channel subunit beta-1

Source gene: SCN1B

Class: DEG_APCC_KENBOX_2

Location: 207:211

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6563

ASA_SCORE: 83.12

COIL: 0.7992

CONS_SCORE: 0.9366

DSS_SCORE: 0.3627

HELIX: 0.1198

FCONS_SCORE: 1.009

RIG_SCORE: 0.7168

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R214Q	TCGA-AX-A2H7	UCEC	TCGA	SKENC	DEG_APCC_KENBOX_2	0.25
p.R214Q	DO218896	SKCA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.25
p.R214Q	DO41044	UCEC	ICGC	SKENC	DEG_APCC_KENBOX_2	0.25
p.A197V	DO1608	BRCA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.0556
p.V214I	DO222905	BTCA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.25
p.V214I	DO233947	GACA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.25
p.E209D	DO7801	COAD	ICGC	SKENC	DEG_APCC_KENBOX_2	0.6758
p.E209D	SIDM00118	Colorectal Carcinoma	GDSC	SKENC	DEG_APCC_KENBOX_2	0.6758
p.E209D	ACH-001081	Colon/Colorectal Cancer	CCLE	SKENC	DEG_APCC_KENBOX_2	0.6758
p.E209D	HCC2998	large_intestine	COSMIC	SKENC	DEG_APCC_KENBOX_2	0.6758
p.S198L	DO8722	COAD	ICGC	SKENC	DEG_APCC_KENBOX_2	0.0833
p.L210P	DO229013	COCA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.7582
p.L210P	DO229005	COCA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.7582
p.L210P	DO234205	ESAD	ICGC	SKENC	DEG_APCC_KENBOX_2	0.7582
p.L210P	DO229489	LAML	ICGC	SKENC	DEG_APCC_KENBOX_2	0.7582
p.L210P	DO229505	LAML	ICGC	SKENC	DEG_APCC_KENBOX_2	0.7582
p.L210P	DO228947	LICA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.7582
p.L210P	DO231114	LUSC	ICGC	SKENC	DEG_APCC_KENBOX_2	0.7582
p.L210P	DO231132	LUSC	ICGC	SKENC	DEG_APCC_KENBOX_2	0.7582
p.L210P	DO231212	LUSC	ICGC	SKENC	DEG_APCC_KENBOX_2	0.7582
p.S198I	DO233620	GACA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.0833
p.S197N	DO233885	GACA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.0556
p.S197N	SIDM00282	Colorectal Carcinoma	GDSC	SKENC	DEG_APCC_KENBOX_2	0.0556
p.S197N	CW-2	large_intestine	COSMIC	SKENC	DEG_APCC_KENBOX_2	0.0556
p.G216V	DO228952	LICA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.1944
p.S212I	DO229036	LICA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.3056
p.S211F	DO222683	MELA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.7982
p.S198A	DO222702	MELA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.0833
p.A217T	DO229470	SKCA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.1667
p.E199K	DO37471	SKCM	ICGC	SKENC	DEG_APCC_KENBOX_2	0.1111
p.V214D	DO42384	UCEC	ICGC	SKENC	DEG_APCC_KENBOX_2	0.25
p.E218K	DO41020	UCEC	ICGC	SKENC	DEG_APCC_KENBOX_2	0.1389
p.C211Y	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	SKENC	DEG_APCC_KENBOX_2	0.5976

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_APCC_KENBOX_2	374:378	SKENC	APC,CDC20,FZR1	0.9637	More...
O14965	Aurora kinase A	DEG_APCC_KENBOX_2	4:8	SKENC	APC,CDC20,FZR1	0.9913	More...
Q07699	Sodium channel subunit beta-1	DEG_APCC_KENBOX_2	207:211	SKENC	APC,CDC20,FZR1	0.6563	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SKENC

Degron related mutations and impact score

Drug responses associated with SCN1B mutations

All proteins holding degron of SKENC