DegronMD - O14965(AURKA)

FUNCTION: Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:26246606, PubMed:12390251, PubMed:18615013, PubMed:11039908, PubMed:17125279, PubMed:17360485). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:26246606, PubMed:14523000). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:18056443, PubMed:15128871, PubMed:14702041, PubMed:11551964, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18615013). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Necessary for proper cilia disassembly prior to mitosis (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G11R	TCGA-76-6660	GBM	TCGA	SKENC	DEG_APCC_KENBOX_2	4:8	Mutation rewiring degron network	0.25
p.G11R	DO223728	GBM	ICGC	SKENC	DEG_APCC_KENBOX_2	4:8	Mutation rewiring degron network	0.25
p.S4Y	TCGA-AC-A23H	BRCA	TCGA	SKENC	DEG_APCC_KENBOX_2	4:8	Mutation altering degron motif	0.712
p.S4Y	DO2401	BRCA	ICGC	SKENC	DEG_APCC_KENBOX_2	4:8	Mutation altering degron motif	0.712
p.S387L	TCGA-DR-A0ZM	CESC	TCGA	QRPMLREVL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.0833
p.S387L	TCGA-FU-A3HY	CESC	TCGA	QRPMLREVL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.0833
p.S387L	DO6254	CESC	ICGC	QRPMLREVL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.0833
p.S387L	DO6284	CESC	ICGC	QRPMLREVL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.0833
p.A15D	TCGA-DU-6407	LGG	TCGA	SKENC	DEG_APCC_KENBOX_2	4:8	Mutation rewiring degron network	0.1389
p.A15D	DO22295	LGG	ICGC	SKENC	DEG_APCC_KENBOX_2	4:8	Mutation rewiring degron network	0.1389
p.A385E	DO48254	ESCA	ICGC	QRPMLREVL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.1389
p.A15T	DO233882	GACA	ICGC	SKENC	DEG_APCC_KENBOX_2	4:8	Mutation rewiring degron network	0.1389
p.A17G	SIDM00396	Acute Myeloid Leukemia	GDSC	SKENC	DEG_APCC_KENBOX_2	4:8	Mutation rewiring degron network	0.0833
p.A17G	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	SKENC	DEG_APCC_KENBOX_2	4:8	Mutation rewiring degron network	0.0833
p.S10P	SIDM00789	Colorectal Carcinoma	GDSC	SKENC	DEG_APCC_KENBOX_2	4:8	Mutation blocking phosphorylation signal	0.7222
p.S10P	ACH-000997	Colon/Colorectal Cancer	CCLE	SKENC	DEG_APCC_KENBOX_2	4:8	Mutation blocking phosphorylation signal	0.7222
p.S10P	ACH-001061	Colon/Colorectal Cancer	CCLE	SKENC	DEG_APCC_KENBOX_2	4:8	Mutation blocking phosphorylation signal	0.7222
p.S10P	HCT-15	large intestine	COSMIC	SKENC	DEG_APCC_KENBOX_2	4:8	Mutation blocking phosphorylation signal	0.7222
p.S361L	SIDM00591	Oral Cavity Carcinoma	GDSC	QRPMLREVL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.0833
p.S361L	ACH-002045	Head and Neck Cancer	CCLE	QRPMLREVL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.0833
p.S361L	HO-1-u-1	upper aerodigestive tract	COSMIC	QRPMLREVL	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.0833
p.E6Q	SIDM01433	Kidney Carcinoma	GDSC	SKENC	DEG_APCC_KENBOX_2	4:8	Mutation altering degron motif	0.6744
p.E6Q	ACH-000317	Kidney Cancer	CCLE	SKENC	DEG_APCC_KENBOX_2	4:8	Mutation altering degron motif	0.6744

Kaplan plot for AURKA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AURKA

UniProt ID: O14965

Entrez ID: 6790

Protein name: Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AURKA in