DegronMD

Uniprot ID: O14965

Source protein: Aurora kinase A

Source gene: AURKA

Class: DEG_APCC_DBOX_1

Location: 370:378

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5969

ASA_SCORE: 67.2333

COIL: 0.4066

CONS_SCORE: 0.686

DSS_SCORE: 0.4658

HELIX: 0.584

FCONS_SCORE: 0.9975

RIG_SCORE: 0.7278

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S387L	TCGA-DR-A0ZM	CESC	TCGA	QRPMLREVL	DEG_APCC_DBOX_1	0.0833
p.S387L	TCGA-FU-A3HY	CESC	TCGA	QRPMLREVL	DEG_APCC_DBOX_1	0.0833
p.S387L	DO6254	CESC	ICGC	QRPMLREVL	DEG_APCC_DBOX_1	0.0833
p.S387L	DO6284	CESC	ICGC	QRPMLREVL	DEG_APCC_DBOX_1	0.0833
p.A385E	DO48254	ESCA	ICGC	QRPMLREVL	DEG_APCC_DBOX_1	0.1389
p.S361L	SIDM00591	Oral Cavity Carcinoma	GDSC	QRPMLREVL	DEG_APCC_DBOX_1	0.0833
p.S361L	ACH-002045	Head and Neck Cancer	CCLE	QRPMLREVL	DEG_APCC_DBOX_1	0.0833
p.S361L	HO-1-u-1	upper_aerodigestive_tract	COSMIC	QRPMLREVL	DEG_APCC_DBOX_1	0.0833

Drug responses associated with AURKA mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01199	LIHC\|liver	p.Y219fs*19 (No)	GDSC	Genentech Cpd 10	0.6872
SIDM01199	LIHC\|liver	p.Y219fs*19 (No)	GDSC	GSK1070916	2.9092
SIDM01199	LIHC\|liver	p.Y219fs*19 (No)	GDSC	Alisertib	1.1305
SIDM01199	LIHC\|liver	p.Y219fs*19 (No)	GDSC	CD532	0.5692
SIDM01199	LIHC\|liver	p.Y219fs*19 (No)	GDSC	ZM447439	33.9808
SIDM01199	LIHC\|liver	p.Y219fs*19 (No)	GDSC	Alisertib	7.0675
SIDM00142	UCEC\|endometrium	p.P110H (No)	GDSC	Tozasertib	2.433
SIDM00142	UCEC\|endometrium	p.P110H (No)	GDSC	Genentech Cpd 10	2.7209
SIDM00142	UCEC\|endometrium	p.P110H (No)	GDSC	GSK1070916	3.4128
SIDM00142	UCEC\|endometrium	p.P110H (No)	GDSC	Alisertib	3.7405
SIDM00142	UCEC\|endometrium	p.P110H (No)	GDSC	CD532	0.6992
SIDM00142	UCEC\|endometrium	p.P110H (No)	GDSC	ZM447439	12.2979
SIDM00142	UCEC\|endometrium	p.P110H (No)	GDSC	Alisertib	21.113
SIDM00591	HNSC\|head_and_neck	p.S361L (Yes)	GDSC	Genentech Cpd 10	19.2562
SIDM00591	HNSC\|head_and_neck	p.S361L (Yes)	GDSC	GSK1070916	13.7121
SIDM00591	HNSC\|head_and_neck	p.S361L (Yes)	GDSC	Alisertib	22.1037
SIDM00591	HNSC\|head_and_neck	p.S361L (Yes)	GDSC	CD532	3.133
SIDM00591	HNSC\|head_and_neck	p.S361L (Yes)	GDSC	ZM447439	22.7627
SIDM00003	SKCM\|melanoma	p.Y246H (No)	GDSC	Genentech Cpd 10	23.8472
SIDM00003	SKCM\|melanoma	p.Y246H (No)	GDSC	GSK1070916	26.6053
SIDM00003	SKCM\|melanoma	p.Y246H (No)	GDSC	Alisertib	27.8959
SIDM00003	SKCM\|melanoma	p.Y246H (No)	GDSC	CD532	1.178
SIDM00003	SKCM\|melanoma	p.Y246H (No)	GDSC	ZM447439	6.8879
SIDM00003	SKCM\|melanoma	p.Y246H (No)	GDSC	Alisertib	12.189
SIDM01090	COREAD\|large_intestine	p.L222P (No)	GDSC	Tozasertib	0.1913
SIDM01090	COREAD\|large_intestine	p.L222P (No)	GDSC	Genentech Cpd 10	8.9894
SIDM01090	COREAD\|large_intestine	p.L222P (No)	GDSC	GSK1070916	1.9018
SIDM01090	COREAD\|large_intestine	p.L222P (No)	GDSC	Alisertib	3.2391
SIDM01090	COREAD\|large_intestine	p.L222P (No)	GDSC	CD532	0.4561
SIDM01090	COREAD\|large_intestine	p.L222P (No)	GDSC	ZM447439	0.5812
SIDM01090	COREAD\|large_intestine	p.L222P (No)	GDSC	Alisertib	6.9302
SIDM00516	SKCM\|melanoma	p.V174M (No)	GDSC	Tozasertib	3.3024
SIDM00516	SKCM\|melanoma	p.V174M (No)	GDSC	Genentech Cpd 10	9.1387
SIDM00516	SKCM\|melanoma	p.V174M (No)	GDSC	GSK1070916	3.5372
SIDM00516	SKCM\|melanoma	p.V174M (No)	GDSC	Alisertib	18.9245
SIDM00516	SKCM\|melanoma	p.V174M (No)	GDSC	CD532	0.563
SIDM00516	SKCM\|melanoma	p.V174M (No)	GDSC	ZM447439	58.1864
SIDM00498	COREAD\|large_intestine	p.V84A (No)	GDSC	Genentech Cpd 10	114.4248
SIDM00498	COREAD\|large_intestine	p.V84A (No)	GDSC	GSK1070916	6.369
SIDM00498	COREAD\|large_intestine	p.V84A (No)	GDSC	Alisertib	7.2486
SIDM00498	COREAD\|large_intestine	p.V84A (No)	GDSC	CD532	3.4432
SIDM00498	COREAD\|large_intestine	p.V84A (No)	GDSC	ZM447439	20.8198
SIDM00498	COREAD\|large_intestine	p.V84A (No)	GDSC	Alisertib	7.4491
SIDM01045	UCEC\|endometrium	p.D311G (No)	GDSC	Genentech Cpd 10	11.2484
SIDM01045	UCEC\|endometrium	p.D311G (No)	GDSC	GSK1070916	1.5977
SIDM01045	UCEC\|endometrium	p.D311G (No)	GDSC	Alisertib	0.5803
SIDM01045	UCEC\|endometrium	p.D311G (No)	GDSC	CD532	1.3103
SIDM01045	UCEC\|endometrium	p.D311G (No)	GDSC	ZM447439	8.0867
SIDM01045	UCEC\|endometrium	p.D311G (No)	GDSC	Alisertib	1.6668
SIDM00898	BRCA\|breast	p.R189X (No)	GDSC	Genentech Cpd 10	3.7688
SIDM00898	BRCA\|breast	p.R189X (No)	GDSC	GSK1070916	30.4305
SIDM00898	BRCA\|breast	p.R189X (No)	GDSC	Alisertib	26.0301
SIDM00898	BRCA\|breast	p.R189X (No)	GDSC	CD532	0.3133
SIDM00898	BRCA\|breast	p.R189X (No)	GDSC	ZM447439	25.678
SIDM00898	BRCA\|breast	p.R189X (No)	GDSC	ZM447439	9.6547
SIDM00898	BRCA\|breast	p.R189X (No)	GDSC	Alisertib	14.767
SIDM00898	BRCA\|breast	p.R189X (No)	GDSC	Tozasertib	81.377
SIDM00396	LAML\|acute_myeloid_leukaemia	p.A17G (No)	GDSC	Tozasertib	0.1296
SIDM00396	LAML\|acute_myeloid_leukaemia	p.A17G (No)	GDSC	Genentech Cpd 10	0.5165
SIDM00396	LAML\|acute_myeloid_leukaemia	p.A17G (No)	GDSC	GSK1070916	0.0219
SIDM00396	LAML\|acute_myeloid_leukaemia	p.A17G (No)	GDSC	Alisertib	0.0596
SIDM00396	LAML\|acute_myeloid_leukaemia	p.A17G (No)	GDSC	CD532	0.0929
SIDM00267	UNCLASSIFIED\|biliary_tract	p.G173V (No)	GDSC	Tozasertib	0.5936
SIDM00267	UNCLASSIFIED\|biliary_tract	p.G173V (No)	GDSC	Genentech Cpd 10	2.7136
SIDM00267	UNCLASSIFIED\|biliary_tract	p.G173V (No)	GDSC	GSK1070916	1.8693
SIDM00267	UNCLASSIFIED\|biliary_tract	p.G173V (No)	GDSC	Alisertib	4.7057
SIDM00267	UNCLASSIFIED\|biliary_tract	p.G173V (No)	GDSC	CD532	0.7067
SIDM00267	UNCLASSIFIED\|biliary_tract	p.G173V (No)	GDSC	ZM447439	12.0764
SIDM00267	UNCLASSIFIED\|biliary_tract	p.G173V (No)	GDSC	Alisertib	1.7926
SIDM00973	SKCM\|melanoma	p.V19L (No)	GDSC	Genentech Cpd 10	124.2932
SIDM00973	SKCM\|melanoma	p.V19L (No)	GDSC	GSK1070916	5.5336
SIDM00973	SKCM\|melanoma	p.V19L (No)	GDSC	Alisertib	15.5686
SIDM00973	SKCM\|melanoma	p.V19L (No)	GDSC	CD532	0.9604
SIDM00973	SKCM\|melanoma	p.V19L (No)	GDSC	ZM447439	4.9606
SIDM00973	SKCM\|melanoma	p.V19L (No)	GDSC	Alisertib	4.7518
SIDM00789	COREAD\|large_intestine	p.T333I (No)	GDSC	Genentech Cpd 10	35.6954
SIDM00789	COREAD\|large_intestine	p.T333I (No)	GDSC	GSK1070916	21.6816
SIDM00789	COREAD\|large_intestine	p.T333I (No)	GDSC	Alisertib	16.0859
SIDM00789	COREAD\|large_intestine	p.T333I (No)	GDSC	CD532	8.1673
SIDM00789	COREAD\|large_intestine	p.T333I (No)	GDSC	ZM447439	17.2239
SIDM00789	COREAD\|large_intestine	p.T333I (No)	GDSC	Alisertib	1.5627
SIDM00789	COREAD\|large_intestine	p.S10P (No)	GDSC	Genentech Cpd 10	35.6954
SIDM00789	COREAD\|large_intestine	p.S10P (No)	GDSC	GSK1070916	21.6816
SIDM00789	COREAD\|large_intestine	p.S10P (No)	GDSC	Alisertib	16.0859
SIDM00789	COREAD\|large_intestine	p.S10P (No)	GDSC	CD532	8.1673
SIDM00789	COREAD\|large_intestine	p.S10P (No)	GDSC	ZM447439	17.2239
SIDM00789	COREAD\|large_intestine	p.S10P (No)	GDSC	Alisertib	1.5627
SIDM00541	COREAD\|large_intestine	p.Y197C (No)	GDSC	Genentech Cpd 10	187.0053
SIDM00541	COREAD\|large_intestine	p.Y197C (No)	GDSC	GSK1070916	75.4087
SIDM00541	COREAD\|large_intestine	p.Y197C (No)	GDSC	Alisertib	15.5709
SIDM00541	COREAD\|large_intestine	p.Y197C (No)	GDSC	CD532	3.426
SIDM00541	COREAD\|large_intestine	p.Y197C (No)	GDSC	ZM447439	73.049
SIDM00541	COREAD\|large_intestine	p.Y197C (No)	GDSC	Alisertib	22.532
SIDM01182	BLCA\|bladder	p.Q29* (No)	GDSC	Genentech Cpd 10	7.409
SIDM01182	BLCA\|bladder	p.Q29* (No)	GDSC	GSK1070916	4.5612
SIDM01182	BLCA\|bladder	p.Q29* (No)	GDSC	Alisertib	0.5331
SIDM01182	BLCA\|bladder	p.Q29* (No)	GDSC	CD532	0.886
SIDM01182	BLCA\|bladder	p.Q29* (No)	GDSC	ZM447439	3.1451
SIDM00537	COREAD\|large_intestine	p.P297H (No)	GDSC	Genentech Cpd 10	7.7672
SIDM00537	COREAD\|large_intestine	p.P297H (No)	GDSC	GSK1070916	6.1729
SIDM00537	COREAD\|large_intestine	p.P297H (No)	GDSC	Alisertib	14.9871
SIDM00537	COREAD\|large_intestine	p.P297H (No)	GDSC	CD532	0.0904
SIDM00537	COREAD\|large_intestine	p.P297H (No)	GDSC	ZM447439	4.2535
SIDM00537	COREAD\|large_intestine	p.P297H (No)	GDSC	Alisertib	2.516
SIDM01131	SCLC\|lung_small_cell_carcinoma	p.R343Q (No)	GDSC	Tozasertib	1.4136
SIDM01131	SCLC\|lung_small_cell_carcinoma	p.R343Q (No)	GDSC	Genentech Cpd 10	14.3273
SIDM01131	SCLC\|lung_small_cell_carcinoma	p.R343Q (No)	GDSC	GSK1070916	0.5153
SIDM01131	SCLC\|lung_small_cell_carcinoma	p.R343Q (No)	GDSC	Alisertib	2.0294
SIDM01131	SCLC\|lung_small_cell_carcinoma	p.R343Q (No)	GDSC	CD532	0.7474
SIDM01131	SCLC\|lung_small_cell_carcinoma	p.R343Q (No)	GDSC	ZM447439	11.195
SIDM01131	SCLC\|lung_small_cell_carcinoma	p.R343Q (No)	GDSC	Alisertib	0.4671
SIDM00878	BRCA\|breast	p.F133L (No)	GDSC	Genentech Cpd 10	7.0448
SIDM00878	BRCA\|breast	p.F133L (No)	GDSC	GSK1070916	2.8763
SIDM00878	BRCA\|breast	p.F133L (No)	GDSC	Alisertib	13.9061
SIDM00878	BRCA\|breast	p.F133L (No)	GDSC	CD532	0.5835
SIDM00878	BRCA\|breast	p.F133L (No)	GDSC	ZM447439	20.7379
SIDM00878	BRCA\|breast	p.F133L (No)	GDSC	ZM447439	4.1209
SIDM00878	BRCA\|breast	p.F133L (No)	GDSC	Alisertib	12.189
SIDM00878	BRCA\|breast	p.F133L (No)	GDSC	Tozasertib	8.1413

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRPMLREVL

Degron related mutations and impact score

Drug responses associated with AURKA mutations

All proteins holding degron of QRPMLREVL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14965	Aurora kinase A	DEG_APCC_DBOX_1	370:378	QRPMLREVL	APC,CDC20,FZR1	0.5969	More...