DegronMD

Uniprot ID: O14965

Source protein: Aurora kinase A

Source gene: AURKA

Class: DEG_APCC_KENBOX_2

Location: 4:8

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9913

ASA_SCORE: 110.5

COIL: 0.8658

CONS_SCORE: 0.4562

DSS_SCORE: 0.7277

HELIX: 0.1214

FCONS_SCORE: 1.0019

RIG_SCORE: 0.7129

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G11R	TCGA-76-6660	GBM	TCGA	SKENC	DEG_APCC_KENBOX_2	0.25
p.G11R	DO223728	GBM	ICGC	SKENC	DEG_APCC_KENBOX_2	0.25
p.S4Y	TCGA-AC-A23H	BRCA	TCGA	SKENC	DEG_APCC_KENBOX_2	0.712
p.S4Y	DO2401	BRCA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.712
p.A15D	TCGA-DU-6407	LGG	TCGA	SKENC	DEG_APCC_KENBOX_2	0.1389
p.A15D	DO22295	LGG	ICGC	SKENC	DEG_APCC_KENBOX_2	0.1389
p.A15T	DO233882	GACA	ICGC	SKENC	DEG_APCC_KENBOX_2	0.1389
p.A17G	SIDM00396	Acute Myeloid Leukemia	GDSC	SKENC	DEG_APCC_KENBOX_2	0.0833
p.A17G	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	SKENC	DEG_APCC_KENBOX_2	0.0833
p.S10P	SIDM00789	Colorectal Carcinoma	GDSC	SKENC	DEG_APCC_KENBOX_2	0.7222
p.S10P	ACH-000997	Colon/Colorectal Cancer	CCLE	SKENC	DEG_APCC_KENBOX_2	0.7222
p.S10P	ACH-001061	Colon/Colorectal Cancer	CCLE	SKENC	DEG_APCC_KENBOX_2	0.7222
p.S10P	HCT-15	large_intestine	COSMIC	SKENC	DEG_APCC_KENBOX_2	0.7222
p.E6Q	SIDM01433	Kidney Carcinoma	GDSC	SKENC	DEG_APCC_KENBOX_2	0.6744
p.E6Q	ACH-000317	Kidney Cancer	CCLE	SKENC	DEG_APCC_KENBOX_2	0.6744

Drug responses associated with AURKA mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01199	LIHC\|liver	p.Y219fs*19 (No)	GDSC	Genentech Cpd 10	0.6872
SIDM01199	LIHC\|liver	p.Y219fs*19 (No)	GDSC	GSK1070916	2.9092
SIDM01199	LIHC\|liver	p.Y219fs*19 (No)	GDSC	Alisertib	1.1305
SIDM01199	LIHC\|liver	p.Y219fs*19 (No)	GDSC	CD532	0.5692
SIDM01199	LIHC\|liver	p.Y219fs*19 (No)	GDSC	ZM447439	33.9808
SIDM01199	LIHC\|liver	p.Y219fs*19 (No)	GDSC	Alisertib	7.0675
SIDM00142	UCEC\|endometrium	p.P110H (No)	GDSC	Tozasertib	2.433
SIDM00142	UCEC\|endometrium	p.P110H (No)	GDSC	Genentech Cpd 10	2.7209
SIDM00142	UCEC\|endometrium	p.P110H (No)	GDSC	GSK1070916	3.4128
SIDM00142	UCEC\|endometrium	p.P110H (No)	GDSC	Alisertib	3.7405
SIDM00142	UCEC\|endometrium	p.P110H (No)	GDSC	CD532	0.6992
SIDM00142	UCEC\|endometrium	p.P110H (No)	GDSC	ZM447439	12.2979
SIDM00142	UCEC\|endometrium	p.P110H (No)	GDSC	Alisertib	21.113
SIDM00591	HNSC\|head_and_neck	p.S361L (No)	GDSC	Genentech Cpd 10	19.2562
SIDM00591	HNSC\|head_and_neck	p.S361L (No)	GDSC	GSK1070916	13.7121
SIDM00591	HNSC\|head_and_neck	p.S361L (No)	GDSC	Alisertib	22.1037
SIDM00591	HNSC\|head_and_neck	p.S361L (No)	GDSC	CD532	3.133
SIDM00591	HNSC\|head_and_neck	p.S361L (No)	GDSC	ZM447439	22.7627
SIDM00003	SKCM\|melanoma	p.Y246H (No)	GDSC	Genentech Cpd 10	23.8472
SIDM00003	SKCM\|melanoma	p.Y246H (No)	GDSC	GSK1070916	26.6053
SIDM00003	SKCM\|melanoma	p.Y246H (No)	GDSC	Alisertib	27.8959
SIDM00003	SKCM\|melanoma	p.Y246H (No)	GDSC	CD532	1.178
SIDM00003	SKCM\|melanoma	p.Y246H (No)	GDSC	ZM447439	6.8879
SIDM00003	SKCM\|melanoma	p.Y246H (No)	GDSC	Alisertib	12.189
SIDM01090	COREAD\|large_intestine	p.L222P (No)	GDSC	Tozasertib	0.1913
SIDM01090	COREAD\|large_intestine	p.L222P (No)	GDSC	Genentech Cpd 10	8.9894
SIDM01090	COREAD\|large_intestine	p.L222P (No)	GDSC	GSK1070916	1.9018
SIDM01090	COREAD\|large_intestine	p.L222P (No)	GDSC	Alisertib	3.2391
SIDM01090	COREAD\|large_intestine	p.L222P (No)	GDSC	CD532	0.4561
SIDM01090	COREAD\|large_intestine	p.L222P (No)	GDSC	ZM447439	0.5812
SIDM01090	COREAD\|large_intestine	p.L222P (No)	GDSC	Alisertib	6.9302
SIDM00516	SKCM\|melanoma	p.V174M (No)	GDSC	Tozasertib	3.3024
SIDM00516	SKCM\|melanoma	p.V174M (No)	GDSC	Genentech Cpd 10	9.1387
SIDM00516	SKCM\|melanoma	p.V174M (No)	GDSC	GSK1070916	3.5372
SIDM00516	SKCM\|melanoma	p.V174M (No)	GDSC	Alisertib	18.9245
SIDM00516	SKCM\|melanoma	p.V174M (No)	GDSC	CD532	0.563
SIDM00516	SKCM\|melanoma	p.V174M (No)	GDSC	ZM447439	58.1864
SIDM00498	COREAD\|large_intestine	p.V84A (No)	GDSC	Genentech Cpd 10	114.4248
SIDM00498	COREAD\|large_intestine	p.V84A (No)	GDSC	GSK1070916	6.369
SIDM00498	COREAD\|large_intestine	p.V84A (No)	GDSC	Alisertib	7.2486
SIDM00498	COREAD\|large_intestine	p.V84A (No)	GDSC	CD532	3.4432
SIDM00498	COREAD\|large_intestine	p.V84A (No)	GDSC	ZM447439	20.8198
SIDM00498	COREAD\|large_intestine	p.V84A (No)	GDSC	Alisertib	7.4491
SIDM01045	UCEC\|endometrium	p.D311G (No)	GDSC	Genentech Cpd 10	11.2484
SIDM01045	UCEC\|endometrium	p.D311G (No)	GDSC	GSK1070916	1.5977
SIDM01045	UCEC\|endometrium	p.D311G (No)	GDSC	Alisertib	0.5803
SIDM01045	UCEC\|endometrium	p.D311G (No)	GDSC	CD532	1.3103
SIDM01045	UCEC\|endometrium	p.D311G (No)	GDSC	ZM447439	8.0867
SIDM01045	UCEC\|endometrium	p.D311G (No)	GDSC	Alisertib	1.6668
SIDM00898	BRCA\|breast	p.R189X (No)	GDSC	Genentech Cpd 10	3.7688
SIDM00898	BRCA\|breast	p.R189X (No)	GDSC	GSK1070916	30.4305
SIDM00898	BRCA\|breast	p.R189X (No)	GDSC	Alisertib	26.0301
SIDM00898	BRCA\|breast	p.R189X (No)	GDSC	CD532	0.3133
SIDM00898	BRCA\|breast	p.R189X (No)	GDSC	ZM447439	25.678
SIDM00898	BRCA\|breast	p.R189X (No)	GDSC	ZM447439	9.6547
SIDM00898	BRCA\|breast	p.R189X (No)	GDSC	Alisertib	14.767
SIDM00898	BRCA\|breast	p.R189X (No)	GDSC	Tozasertib	81.377
SIDM00396	LAML\|acute_myeloid_leukaemia	p.A17G (Yes)	GDSC	Tozasertib	0.1296
SIDM00396	LAML\|acute_myeloid_leukaemia	p.A17G (Yes)	GDSC	Genentech Cpd 10	0.5165
SIDM00396	LAML\|acute_myeloid_leukaemia	p.A17G (Yes)	GDSC	GSK1070916	0.0219
SIDM00396	LAML\|acute_myeloid_leukaemia	p.A17G (Yes)	GDSC	Alisertib	0.0596
SIDM00396	LAML\|acute_myeloid_leukaemia	p.A17G (Yes)	GDSC	CD532	0.0929
SIDM00267	UNCLASSIFIED\|biliary_tract	p.G173V (No)	GDSC	Tozasertib	0.5936
SIDM00267	UNCLASSIFIED\|biliary_tract	p.G173V (No)	GDSC	Genentech Cpd 10	2.7136
SIDM00267	UNCLASSIFIED\|biliary_tract	p.G173V (No)	GDSC	GSK1070916	1.8693
SIDM00267	UNCLASSIFIED\|biliary_tract	p.G173V (No)	GDSC	Alisertib	4.7057
SIDM00267	UNCLASSIFIED\|biliary_tract	p.G173V (No)	GDSC	CD532	0.7067
SIDM00267	UNCLASSIFIED\|biliary_tract	p.G173V (No)	GDSC	ZM447439	12.0764
SIDM00267	UNCLASSIFIED\|biliary_tract	p.G173V (No)	GDSC	Alisertib	1.7926
SIDM00973	SKCM\|melanoma	p.V19L (Yes)	GDSC	Genentech Cpd 10	124.2932
SIDM00973	SKCM\|melanoma	p.V19L (Yes)	GDSC	GSK1070916	5.5336
SIDM00973	SKCM\|melanoma	p.V19L (Yes)	GDSC	Alisertib	15.5686
SIDM00973	SKCM\|melanoma	p.V19L (Yes)	GDSC	CD532	0.9604
SIDM00973	SKCM\|melanoma	p.V19L (Yes)	GDSC	ZM447439	4.9606
SIDM00973	SKCM\|melanoma	p.V19L (Yes)	GDSC	Alisertib	4.7518
SIDM00789	COREAD\|large_intestine	p.T333I (No)	GDSC	Genentech Cpd 10	35.6954
SIDM00789	COREAD\|large_intestine	p.T333I (No)	GDSC	GSK1070916	21.6816
SIDM00789	COREAD\|large_intestine	p.T333I (No)	GDSC	Alisertib	16.0859
SIDM00789	COREAD\|large_intestine	p.T333I (No)	GDSC	CD532	8.1673
SIDM00789	COREAD\|large_intestine	p.T333I (No)	GDSC	ZM447439	17.2239
SIDM00789	COREAD\|large_intestine	p.T333I (No)	GDSC	Alisertib	1.5627
SIDM00789	COREAD\|large_intestine	p.S10P (Yes)	GDSC	Genentech Cpd 10	35.6954
SIDM00789	COREAD\|large_intestine	p.S10P (Yes)	GDSC	GSK1070916	21.6816
SIDM00789	COREAD\|large_intestine	p.S10P (Yes)	GDSC	Alisertib	16.0859
SIDM00789	COREAD\|large_intestine	p.S10P (Yes)	GDSC	CD532	8.1673
SIDM00789	COREAD\|large_intestine	p.S10P (Yes)	GDSC	ZM447439	17.2239
SIDM00789	COREAD\|large_intestine	p.S10P (Yes)	GDSC	Alisertib	1.5627
SIDM00541	COREAD\|large_intestine	p.Y197C (No)	GDSC	Genentech Cpd 10	187.0053
SIDM00541	COREAD\|large_intestine	p.Y197C (No)	GDSC	GSK1070916	75.4087
SIDM00541	COREAD\|large_intestine	p.Y197C (No)	GDSC	Alisertib	15.5709
SIDM00541	COREAD\|large_intestine	p.Y197C (No)	GDSC	CD532	3.426
SIDM00541	COREAD\|large_intestine	p.Y197C (No)	GDSC	ZM447439	73.049
SIDM00541	COREAD\|large_intestine	p.Y197C (No)	GDSC	Alisertib	22.532
SIDM01182	BLCA\|bladder	p.Q29* (No)	GDSC	Genentech Cpd 10	7.409
SIDM01182	BLCA\|bladder	p.Q29* (No)	GDSC	GSK1070916	4.5612
SIDM01182	BLCA\|bladder	p.Q29* (No)	GDSC	Alisertib	0.5331
SIDM01182	BLCA\|bladder	p.Q29* (No)	GDSC	CD532	0.886
SIDM01182	BLCA\|bladder	p.Q29* (No)	GDSC	ZM447439	3.1451
SIDM00537	COREAD\|large_intestine	p.P297H (No)	GDSC	Genentech Cpd 10	7.7672
SIDM00537	COREAD\|large_intestine	p.P297H (No)	GDSC	GSK1070916	6.1729
SIDM00537	COREAD\|large_intestine	p.P297H (No)	GDSC	Alisertib	14.9871
SIDM00537	COREAD\|large_intestine	p.P297H (No)	GDSC	CD532	0.0904
SIDM00537	COREAD\|large_intestine	p.P297H (No)	GDSC	ZM447439	4.2535
SIDM00537	COREAD\|large_intestine	p.P297H (No)	GDSC	Alisertib	2.516
SIDM01131	SCLC\|lung_small_cell_carcinoma	p.R343Q (No)	GDSC	Tozasertib	1.4136
SIDM01131	SCLC\|lung_small_cell_carcinoma	p.R343Q (No)	GDSC	Genentech Cpd 10	14.3273
SIDM01131	SCLC\|lung_small_cell_carcinoma	p.R343Q (No)	GDSC	GSK1070916	0.5153
SIDM01131	SCLC\|lung_small_cell_carcinoma	p.R343Q (No)	GDSC	Alisertib	2.0294
SIDM01131	SCLC\|lung_small_cell_carcinoma	p.R343Q (No)	GDSC	CD532	0.7474
SIDM01131	SCLC\|lung_small_cell_carcinoma	p.R343Q (No)	GDSC	ZM447439	11.195
SIDM01131	SCLC\|lung_small_cell_carcinoma	p.R343Q (No)	GDSC	Alisertib	0.4671
SIDM00878	BRCA\|breast	p.F133L (No)	GDSC	Genentech Cpd 10	7.0448
SIDM00878	BRCA\|breast	p.F133L (No)	GDSC	GSK1070916	2.8763
SIDM00878	BRCA\|breast	p.F133L (No)	GDSC	Alisertib	13.9061
SIDM00878	BRCA\|breast	p.F133L (No)	GDSC	CD532	0.5835
SIDM00878	BRCA\|breast	p.F133L (No)	GDSC	ZM447439	20.7379
SIDM00878	BRCA\|breast	p.F133L (No)	GDSC	ZM447439	4.1209
SIDM00878	BRCA\|breast	p.F133L (No)	GDSC	Alisertib	12.189
SIDM00878	BRCA\|breast	p.F133L (No)	GDSC	Tozasertib	8.1413

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_APCC_KENBOX_2	374:378	SKENC	APC,CDC20,FZR1	0.9637	More...
O14965	Aurora kinase A	DEG_APCC_KENBOX_2	4:8	SKENC	APC,CDC20,FZR1	0.9913	More...
Q07699	Sodium channel subunit beta-1	DEG_APCC_KENBOX_2	207:211	SKENC	APC,CDC20,FZR1	0.6563	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SKENC

Degron related mutations and impact score

Drug responses associated with AURKA mutations

All proteins holding degron of SKENC