DegronMD

Uniprot ID: Q9UBT2

Source protein: SUMO-activating enzyme subunit 2

Source gene: UBA2

Class: DEG_APCC_KENBOX_2

Location: 616:620

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9466

ASA_SCORE: 114.36

COIL: 0.5308

CONS_SCORE: 0.2499

DSS_SCORE: 0.4328

HELIX: 0.4642

FCONS_SCORE: 0.98

RIG_SCORE: 0.6831

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R610H	TCGA-AA-3685	COAD	TCGA	EKENL	DEG_APCC_KENBOX_2	0.1667
p.R610H	TCGA-D1-A16F	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.1667
p.R610H	TCGA-G4-6320	COAD	TCGA	EKENL	DEG_APCC_KENBOX_2	0.1667
p.R610H	DO8047	COAD	ICGC	EKENL	DEG_APCC_KENBOX_2	0.1667
p.R610H	DO8159	COAD	ICGC	EKENL	DEG_APCC_KENBOX_2	0.1667
p.R610H	DO222765	COCA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.1667
p.R610H	DO42408	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.1667
p.K623N	TCGA-BS-A0UF	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.6944
p.K623N	DO41488	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.6944
p.E607Q	TCGA-GD-A6C6	BLCA	TCGA	EKENL	DEG_APCC_KENBOX_2	0.0833
p.E607Q	DO48504	BLCA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.0833
p.K613T	DO233951	GACA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.3611
p.R626L	DO229022	LICA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.1667
p.E607D	DO23294	LINC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.0833
p.R610C	DO232761	PBCA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.1667
p.R626H	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	EKENL	DEG_APCC_KENBOX_2	0.1667
p.R626H	ACH-000717	Esophageal Cancer	CCLE	EKENL	DEG_APCC_KENBOX_2	0.1667
p.R626H	ACH-001369	Ovarian Cancer	CCLE	EKENL	DEG_APCC_KENBOX_2	0.1667
p.R626H	COLO-680N	oesophagus	COSMIC	EKENL	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_APCC_KENBOX_2	4:8	EKENL	APC,CDC20,FZR1	0.7413	More...
P52179	Myomesin-1	DEG_APCC_KENBOX_2	128:132	EKENL	APC,CDC20,FZR1	0.9051	More...
Q3V6T2	Girdin	DEG_APCC_KENBOX_2	381:385	EKENL	APC,CDC20,FZR1	0.5571	More...
Q5VZM2	Ras-related GTP-binding protein B	DEG_APCC_KENBOX_2	11:15	EKENL	APC,CDC20,FZR1	0.8752	More...
Q71F23	Centromere protein U	DEG_APCC_KENBOX_2	196:200	EKENL	APC,CDC20,FZR1	0.9329	More...
Q8NEM0	Microcephalin	DEG_APCC_KENBOX_2	598:602	EKENL	APC,CDC20,FZR1	0.971	More...
Q9H0I2	Enkurin domain-containing protein 1	DEG_APCC_KENBOX_2	101:105	EKENL	APC,CDC20,FZR1	0.9868	More...
Q9UBT2	SUMO-activating enzyme subunit 2	DEG_APCC_KENBOX_2	616:620	EKENL	APC,CDC20,FZR1	0.9466	More...
Q9ULW0	Targeting protein for Xklp2	DEG_APCC_KENBOX_2	86:90	EKENL	APC,CDC20,FZR1	0.9952	More...
A6NNH2	Protein FAM90A27P	DEG_APCC_KENBOX_2	77:81	EKENL	APC,CDC20,FZR1	0.9811	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons