DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
EKENL
Uniprot ID:
A6NNH2
Source protein:
Protein FAM90A27P
Source gene:
FAM90A27P
Class:
DEG_APCC_KENBOX_2
Location:
77:81
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9811
ASA_SCORE:
107.94
COIL:
0.7744
CONS_SCORE:
0.7341
DSS_SCORE:
0.5989
HELIX:
0.1784
FCONS_SCORE:
2.5691
RIG_SCORE:
0.6828
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FAM90A27P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of EKENL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A0AVK6
Transcription factor E2F8
DEG_APCC_KENBOX_2
4:8
EKENL
APC,CDC20,FZR1
0.7413
More...
P52179
Myomesin-1
DEG_APCC_KENBOX_2
128:132
EKENL
APC,CDC20,FZR1
0.9051
More...
Q3V6T2
Girdin
DEG_APCC_KENBOX_2
381:385
EKENL
APC,CDC20,FZR1
0.5571
More...
Q5VZM2
Ras-related GTP-binding protein B
DEG_APCC_KENBOX_2
11:15
EKENL
APC,CDC20,FZR1
0.8752
More...
Q71F23
Centromere protein U
DEG_APCC_KENBOX_2
196:200
EKENL
APC,CDC20,FZR1
0.9329
More...
Q8NEM0
Microcephalin
DEG_APCC_KENBOX_2
598:602
EKENL
APC,CDC20,FZR1
0.971
More...
Q9H0I2
Enkurin domain-containing protein 1
DEG_APCC_KENBOX_2
101:105
EKENL
APC,CDC20,FZR1
0.9868
More...
Q9UBT2
SUMO-activating enzyme subunit 2
DEG_APCC_KENBOX_2
616:620
EKENL
APC,CDC20,FZR1
0.9466
More...
Q9ULW0
Targeting protein for Xklp2
DEG_APCC_KENBOX_2
86:90
EKENL
APC,CDC20,FZR1
0.9952
More...
A6NNH2
Protein FAM90A27P
DEG_APCC_KENBOX_2
77:81
EKENL
APC,CDC20,FZR1
0.9811
More...