DegronMD

Uniprot ID: Q5VZM2

Source protein: Ras-related GTP-binding protein B

Source gene: RRAGB

Class: DEG_APCC_KENBOX_2

Location: 11:15

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8752

ASA_SCORE: 107.8

COIL: 0.725

CONS_SCORE: 0.2965

DSS_SCORE: 0.8154

HELIX: 0.2198

FCONS_SCORE: 0.9945

RIG_SCORE: 0.6504

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E3K	TCGA-44-7670	LUAD	TCGA	EKENL	DEG_APCC_KENBOX_2	0.1111
p.E3K	DO23555	LUAD	ICGC	EKENL	DEG_APCC_KENBOX_2	0.1111
p.R18I	TCGA-AP-A1E0	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.25
p.R18I	DO43154	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.25
p.N14Y	TCGA-B5-A1MW	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.7059
p.N14Y	DO42913	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.7059
p.D5N	TCGA-BQ-7051	KIRP	TCGA	EKENL	DEG_APCC_KENBOX_2	0.1667
p.D5N	DO20778	KIRP	ICGC	EKENL	DEG_APCC_KENBOX_2	0.1667
p.K12R	TCGA-FI-A2D5	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.7237
p.K12R	DO41331	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.7237
p.M19I	TCGA-YD-A89C	SKCM	TCGA	EKENL	DEG_APCC_KENBOX_2	0.2222
p.M19I	DO219501	SKCM	ICGC	EKENL	DEG_APCC_KENBOX_2	0.2222
p.M19I	SIDM00720	Mesothelioma	GDSC	EKENL	DEG_APCC_KENBOX_2	0.2222
p.M19I	ACH-000648	Lung Cancer	CCLE	EKENL	DEG_APCC_KENBOX_2	0.2222
p.M19I	NCI-H28	pleura	COSMIC	EKENL	DEG_APCC_KENBOX_2	0.2222
p.D5H	DO223045	ESCA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.1667
p.S4F	SIDM01323	Oral Cavity Carcinoma	GDSC	EKENL	DEG_APCC_KENBOX_2	0.5833
p.S4F	ACH-000732	Head and Neck Cancer	CCLE	EKENL	DEG_APCC_KENBOX_2	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_APCC_KENBOX_2	4:8	EKENL	APC,CDC20,FZR1	0.7413	More...
P52179	Myomesin-1	DEG_APCC_KENBOX_2	128:132	EKENL	APC,CDC20,FZR1	0.9051	More...
Q3V6T2	Girdin	DEG_APCC_KENBOX_2	381:385	EKENL	APC,CDC20,FZR1	0.5571	More...
Q5VZM2	Ras-related GTP-binding protein B	DEG_APCC_KENBOX_2	11:15	EKENL	APC,CDC20,FZR1	0.8752	More...
Q71F23	Centromere protein U	DEG_APCC_KENBOX_2	196:200	EKENL	APC,CDC20,FZR1	0.9329	More...
Q8NEM0	Microcephalin	DEG_APCC_KENBOX_2	598:602	EKENL	APC,CDC20,FZR1	0.971	More...
Q9H0I2	Enkurin domain-containing protein 1	DEG_APCC_KENBOX_2	101:105	EKENL	APC,CDC20,FZR1	0.9868	More...
Q9UBT2	SUMO-activating enzyme subunit 2	DEG_APCC_KENBOX_2	616:620	EKENL	APC,CDC20,FZR1	0.9466	More...
Q9ULW0	Targeting protein for Xklp2	DEG_APCC_KENBOX_2	86:90	EKENL	APC,CDC20,FZR1	0.9952	More...
A6NNH2	Protein FAM90A27P	DEG_APCC_KENBOX_2	77:81	EKENL	APC,CDC20,FZR1	0.9811	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons