DegronMD - Q9UBT2(UBA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A581G	TCGA-39-5011	LUSC	TCGA	PSTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.3056
p.A581G	DO27532	LUSC	ICGC	PSTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.3056
p.L588V	TCGA-A2-A0EV	BRCA	TCGA	PSTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1111
p.L588V	DO4942	BRCA	ICGC	PSTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1111
p.R610H	TCGA-AA-3685	COAD	TCGA	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation rewiring degron network	0.1667
p.R610H	TCGA-D1-A16F	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation rewiring degron network	0.1667
p.R610H	TCGA-G4-6320	COAD	TCGA	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation rewiring degron network	0.1667
p.R610H	DO8047	COAD	ICGC	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation rewiring degron network	0.1667
p.R610H	DO8159	COAD	ICGC	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation rewiring degron network	0.1667
p.R610H	DO222765	COCA	ICGC	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation rewiring degron network	0.1667
p.R610H	DO42408	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation rewiring degron network	0.1667
p.D585N	TCGA-B5-A1MX	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1944
p.D585N	DO41999	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1944
p.V587I	TCGA-B5-A3FC	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1389
p.V587I	DO41871	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1389
p.S577Y	TCGA-BQ-7044	KIRP	TCGA	PSTST	DEG_SPOP_SBC_1	576:580	Mutation altering degron motif	0.6009
p.S577Y	DO20942	KIRP	ICGC	PSTST	DEG_SPOP_SBC_1	576:580	Mutation altering degron motif	0.6009
p.K623N	TCGA-BS-A0UF	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation blocking ubiquitination signal	0.6944
p.K623N	DO41488	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation blocking ubiquitination signal	0.6944
p.E607Q	TCGA-GD-A6C6	BLCA	TCGA	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation rewiring degron network	0.0833
p.E607Q	DO48504	BLCA	ICGC	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation rewiring degron network	0.0833
p.N568Y	TCGA-IN-A6RO	STAD	TCGA	PSTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1111
p.N568Y	DO51740	STAD	ICGC	PSTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.1111
p.S579T	TCGA-S9-A7QZ	LGG	TCGA	PSTST	DEG_SPOP_SBC_1	576:580	Mutation altering degron motif	0.6005
p.S579T	DO50216	LGG	ICGC	PSTST	DEG_SPOP_SBC_1	576:580	Mutation altering degron motif	0.6005
p.K613T	DO233951	GACA	ICGC	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation substituting flanking lysine	0.3611
p.R626L	DO229022	LICA	ICGC	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation rewiring degron network	0.1667
p.E607D	DO23294	LINC	ICGC	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation rewiring degron network	0.0833
p.G573V	DO23196	LINC	ICGC	PSTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.25
p.G573R	DO23196	LINC	ICGC	PSTST	DEG_SPOP_SBC_1	576:580	Mutation rewiring degron network	0.25
p.R610C	DO232761	PBCA	ICGC	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation rewiring degron network	0.1667
p.R626H	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation rewiring degron network	0.1667
p.R626H	ACH-000717	Esophageal Cancer	CCLE	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation rewiring degron network	0.1667
p.R626H	ACH-001369	Ovarian Cancer	CCLE	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation rewiring degron network	0.1667
p.R626H	COLO-680N	oesophagus	COSMIC	EKENL	DEG_APCC_KENBOX_2	616:620	Mutation rewiring degron network	0.1667

Kaplan plot for UBA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBA2

UniProt ID: Q9UBT2

Entrez ID: 10054

Protein name: SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBA2 in