DegronMD - P52179(MYOM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1168Q	TCGA-67-3772	LUAD	TCGA	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation altering degron motif	0.6744
p.W303C	TCGA-A5-A0G1	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation rewiring degron network	0.0833
p.W303C	DO42472	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation rewiring degron network	0.0833
p.A301S	TCGA-A5-A0G1	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation rewiring degron network	0.1389
p.A301S	DO42472	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation rewiring degron network	0.1389
p.F1169L	TCGA-AG-A002	READ	TCGA	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation rewiring degron network	0.3056
p.F1169L	TCGA-EO-A3AY	UCEC	TCGA	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation rewiring degron network	0.3056
p.A119T	TCGA-AX-A1CE	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	128:132	Mutation rewiring degron network	0.0833
p.A119T	DO42280	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	128:132	Mutation rewiring degron network	0.0833
p.V288A	TCGA-AX-A2HJ	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation rewiring degron network	0.2778
p.V288A	DO42105	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation rewiring degron network	0.2778
p.D1174Y	TCGA-B5-A0K8	UCEC	TCGA	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation rewiring degron network	0.1667
p.D1174Y	TCGA-BK-A6W3	UCEC	TCGA	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation rewiring degron network	0.1667
p.P1165L	TCGA-BF-A5EQ	SKCM	TCGA	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation altering degron motif	0.7582
p.E1168K	TCGA-BF-AAP2	SKCM	TCGA	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation altering degron motif	0.7022
p.E1168K	SIDM01608	Endometrial Carcinoma	GDSC	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation altering degron motif	0.7022
p.E1168K	ACH-000990	Endometrial/Uterine Cancer	CCLE	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation altering degron motif	0.7022
p.S1155L	TCGA-CV-7411	HNSC	TCGA	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation rewiring degron network	0.1111
p.V1176A	TCGA-D1-A15X	UCEC	TCGA	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation rewiring degron network	0.1111
p.E292D	TCGA-D1-A17Q	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation altering degron motif	0.6758
p.E292D	DO41903	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation altering degron motif	0.6758
p.L123I	TCGA-D3-A2JP	SKCM	TCGA	EKENL	DEG_APCC_KENBOX_2	128:132	Mutation rewiring degron network	0.1944
p.L123I	DO47407	SKCM	ICGC	EKENL	DEG_APCC_KENBOX_2	128:132	Mutation rewiring degron network	0.1944
p.E1168G	TCGA-E6-A1LX	UCEC	TCGA	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation altering degron motif	0.7199
p.G302D	TCGA-E9-A1R4	BRCA	TCGA	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation rewiring degron network	0.1111
p.G302D	DO5815	BRCA	ICGC	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation rewiring degron network	0.1111
p.D1174N	TCGA-EE-A29V	SKCM	TCGA	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation rewiring degron network	0.1667
p.L296V	TCGA-EO-A22R	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation rewiring degron network	0.2778
p.L296V	DO42713	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation rewiring degron network	0.2778
p.R284C	TCGA-EY-A5W2	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation rewiring degron network	0.1667
p.R284C	DO48177	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation rewiring degron network	0.1667
p.I300V	TCGA-O2-A52N	LUSC	TCGA	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation rewiring degron network	0.1667
p.I300V	DO219217	LUSC	ICGC	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation rewiring degron network	0.1667
p.K120N	TCGA-SJ-A6ZI	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	128:132	Mutation substituting flanking lysine	0.2222
p.K120N	DO219784	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	128:132	Mutation substituting flanking lysine	0.2222
p.S1167Y	TCGA-VQ-A8P2	STAD	TCGA	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation altering degron motif	0.6009
p.R1165Q	DO219733	CESC	ICGC	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation altering degron motif	0.7329
p.H297L	DO233140	GACA	ICGC	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation rewiring degron network	0.25
p.A1155V	DO13522	GBM	ICGC	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation rewiring degron network	0.1111
p.A119D	DO229015	LICA	ICGC	EKENL	DEG_APCC_KENBOX_2	128:132	Mutation rewiring degron network	0.0833
p.A119D	DO229026	LICA	ICGC	EKENL	DEG_APCC_KENBOX_2	128:132	Mutation rewiring degron network	0.0833
p.T287K	DO231049	LUSC	ICGC	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation rewiring degron network	0.25
p.L132F	DO52649	MALY	ICGC	EKENL	DEG_APCC_KENBOX_2	128:132	Mutation altering degron motif	0.587
p.E130K	DO222843	MELA	ICGC	EKENL	DEG_APCC_KENBOX_2	128:132	Mutation altering degron motif	0.7022
p.L1154S	DO51761	STAD	ICGC	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation rewiring degron network	0.0833
p.G1162S	DO40954	UCEC	ICGC	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation rewiring degron network	0.3056
p.G1162S	DO52421	UCEC	ICGC	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation rewiring degron network	0.3056
p.P1165S	SIDM01034	B-Lymphoblastic Leukemia	GDSC	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation altering degron motif	0.6752
p.P1165S	SIDM00466	Ovarian Carcinoma	GDSC	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation altering degron motif	0.6752
p.P1165S	SIDM00351	Oral Cavity Carcinoma	GDSC	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation altering degron motif	0.6752
p.P1165S	SIDM01172	Acute Myeloid Leukemia	GDSC	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation altering degron motif	0.6752
p.P1165S	SIDM01451	Pancreatic Carcinoma	GDSC	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation altering degron motif	0.6752
p.P1165S	SIDM00159	Biliary Tract Carcinoma	GDSC	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation altering degron motif	0.6752
p.W1171L	SIDM00466	Ovarian Carcinoma	GDSC	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation rewiring degron network	0.25
p.W1171L	ACH-000443	Ovarian Cancer	CCLE	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation rewiring degron network	0.25
p.W1171L	OVKATE	ovary	COSMIC	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation rewiring degron network	0.25
p.S1170A	ACH-001970	Metastasis	CCLE	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation blocking phosphorylation signal	0.7222
p.Y1159C	GP5d	large intestine	COSMIC	MTPKSE	DEG_SCF_FBW7_2	1163:1168	Mutation rewiring degron network	0.2222
p.P296S	EN	endometrium	COSMIC	EKENV	DEG_APCC_KENBOX_2	290:294	Mutation rewiring degron network	0.2778
p.E126D	H513	pleura	COSMIC	EKENL	DEG_APCC_KENBOX_2	128:132	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYOM1

UniProt ID: P52179

Entrez ID: 8736

Protein name: Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYOM1 in