DegronMD

Uniprot ID: P52179

Source protein: Myomesin-1

Source gene: MYOM1

Class: DEG_APCC_KENBOX_2

Location: 128:132

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9051

ASA_SCORE: 102.18

COIL: 0.5106

CONS_SCORE: 0.5746

DSS_SCORE: 0.4647

HELIX: 0.0248

FCONS_SCORE: 1.1293

RIG_SCORE: 0.6724

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A119T	TCGA-AX-A1CE	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.0833
p.A119T	DO42280	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.0833
p.L123I	TCGA-D3-A2JP	SKCM	TCGA	EKENL	DEG_APCC_KENBOX_2	0.1944
p.L123I	DO47407	SKCM	ICGC	EKENL	DEG_APCC_KENBOX_2	0.1944
p.K120N	TCGA-SJ-A6ZI	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.2222
p.K120N	DO219784	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.2222
p.A119D	DO229015	LICA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.0833
p.A119D	DO229026	LICA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.0833
p.L132F	DO52649	MALY	ICGC	EKENL	DEG_APCC_KENBOX_2	0.587
p.E130K	DO222843	MELA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.7022
p.E126D	H513	pleura	COSMIC	EKENL	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_APCC_KENBOX_2	4:8	EKENL	APC,CDC20,FZR1	0.7413	More...
P52179	Myomesin-1	DEG_APCC_KENBOX_2	128:132	EKENL	APC,CDC20,FZR1	0.9051	More...
Q3V6T2	Girdin	DEG_APCC_KENBOX_2	381:385	EKENL	APC,CDC20,FZR1	0.5571	More...
Q5VZM2	Ras-related GTP-binding protein B	DEG_APCC_KENBOX_2	11:15	EKENL	APC,CDC20,FZR1	0.8752	More...
Q71F23	Centromere protein U	DEG_APCC_KENBOX_2	196:200	EKENL	APC,CDC20,FZR1	0.9329	More...
Q8NEM0	Microcephalin	DEG_APCC_KENBOX_2	598:602	EKENL	APC,CDC20,FZR1	0.971	More...
Q9H0I2	Enkurin domain-containing protein 1	DEG_APCC_KENBOX_2	101:105	EKENL	APC,CDC20,FZR1	0.9868	More...
Q9UBT2	SUMO-activating enzyme subunit 2	DEG_APCC_KENBOX_2	616:620	EKENL	APC,CDC20,FZR1	0.9466	More...
Q9ULW0	Targeting protein for Xklp2	DEG_APCC_KENBOX_2	86:90	EKENL	APC,CDC20,FZR1	0.9952	More...
A6NNH2	Protein FAM90A27P	DEG_APCC_KENBOX_2	77:81	EKENL	APC,CDC20,FZR1	0.9811	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons