DegronMD - Q9ULW0(TPX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E92V	TCGA-BH-A0BZ	BRCA	TCGA	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.2778
p.E92V	DO1396	BRCA	ICGC	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.2778
p.P96S	TCGA-BH-A0BZ	BRCA	TCGA	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.1667
p.P96S	DO1396	BRCA	ICGC	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.1667
p.T80I	TCGA-CK-4951	COAD	TCGA	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.1667
p.T80I	DO10582	COAD	ICGC	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.1667
p.A85T	TCGA-EO-A3KX	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.3056
p.A85T	DO219774	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.3056
p.A99S	TCGA-N8-A4PM	UCS	TCGA	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.0833
p.A99S	DO229019	LICA	ICGC	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.0833
p.I95F	SIDM01019	Acute Myeloid Leukemia	GDSC	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.1944
p.I95F	ACH-002258	Leukemia	CCLE	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.1944
p.I95F	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.1944
p.L90R	SIDM01217	Other Blood Cancers	GDSC	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation altering degron motif	0.7316
p.L90R	ACH-002276	Leukemia	CCLE	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation altering degron motif	0.7316
p.L90R	MY-M12	haematopoietic and lymphoid tissue	COSMIC	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation altering degron motif	0.7316
p.A99V	ACH-000430	Ovarian Cancer	CCLE	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.0833
p.A99V	TYK-nu	ovary	COSMIC	EKENL	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.0833

Kaplan plot for TPX2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TPX2

UniProt ID: Q9ULW0

Entrez ID: 22974

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TPX2 in