DegronMD

Uniprot ID: Q9ULW0

Source protein: Targeting protein for Xklp2

Source gene: TPX2

Class: DEG_APCC_KENBOX_2

Location: 86:90

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9952

ASA_SCORE: 111.12

COIL: 0.5426

CONS_SCORE: 0.36

DSS_SCORE: 0.4223

HELIX: 0.427

FCONS_SCORE: 1.0374

RIG_SCORE: 0.7902

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E92V	TCGA-BH-A0BZ	BRCA	TCGA	EKENL	DEG_APCC_KENBOX_2	0.2778
p.E92V	DO1396	BRCA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.2778
p.P96S	TCGA-BH-A0BZ	BRCA	TCGA	EKENL	DEG_APCC_KENBOX_2	0.1667
p.P96S	DO1396	BRCA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.1667
p.T80I	TCGA-CK-4951	COAD	TCGA	EKENL	DEG_APCC_KENBOX_2	0.1667
p.T80I	DO10582	COAD	ICGC	EKENL	DEG_APCC_KENBOX_2	0.1667
p.A85T	TCGA-EO-A3KX	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.3056
p.A85T	DO219774	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.3056
p.A99S	TCGA-N8-A4PM	UCS	TCGA	EKENL	DEG_APCC_KENBOX_2	0.0833
p.A99S	DO229019	LICA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.0833
p.I95F	SIDM01019	Acute Myeloid Leukemia	GDSC	EKENL	DEG_APCC_KENBOX_2	0.1944
p.I95F	ACH-002258	Leukemia	CCLE	EKENL	DEG_APCC_KENBOX_2	0.1944
p.I95F	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	EKENL	DEG_APCC_KENBOX_2	0.1944
p.L90R	SIDM01217	Other Blood Cancers	GDSC	EKENL	DEG_APCC_KENBOX_2	0.7316
p.L90R	ACH-002276	Leukemia	CCLE	EKENL	DEG_APCC_KENBOX_2	0.7316
p.L90R	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	EKENL	DEG_APCC_KENBOX_2	0.7316
p.A99V	ACH-000430	Ovarian Cancer	CCLE	EKENL	DEG_APCC_KENBOX_2	0.0833
p.A99V	TYK-nu	ovary	COSMIC	EKENL	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_APCC_KENBOX_2	4:8	EKENL	APC,CDC20,FZR1	0.7413	More...
P52179	Myomesin-1	DEG_APCC_KENBOX_2	128:132	EKENL	APC,CDC20,FZR1	0.9051	More...
Q3V6T2	Girdin	DEG_APCC_KENBOX_2	381:385	EKENL	APC,CDC20,FZR1	0.5571	More...
Q5VZM2	Ras-related GTP-binding protein B	DEG_APCC_KENBOX_2	11:15	EKENL	APC,CDC20,FZR1	0.8752	More...
Q71F23	Centromere protein U	DEG_APCC_KENBOX_2	196:200	EKENL	APC,CDC20,FZR1	0.9329	More...
Q8NEM0	Microcephalin	DEG_APCC_KENBOX_2	598:602	EKENL	APC,CDC20,FZR1	0.971	More...
Q9H0I2	Enkurin domain-containing protein 1	DEG_APCC_KENBOX_2	101:105	EKENL	APC,CDC20,FZR1	0.9868	More...
Q9UBT2	SUMO-activating enzyme subunit 2	DEG_APCC_KENBOX_2	616:620	EKENL	APC,CDC20,FZR1	0.9466	More...
Q9ULW0	Targeting protein for Xklp2	DEG_APCC_KENBOX_2	86:90	EKENL	APC,CDC20,FZR1	0.9952	More...
A6NNH2	Protein FAM90A27P	DEG_APCC_KENBOX_2	77:81	EKENL	APC,CDC20,FZR1	0.9811	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons