DegronMD

Uniprot ID: Q3V6T2

Source protein: Girdin

Source gene: CCDC88A

Class: DEG_APCC_KENBOX_2

Location: 381:385

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5571

ASA_SCORE: 109.32

COIL: 0.0124

CONS_SCORE: 0.7552

DSS_SCORE: 0.4347

HELIX: 0.988

FCONS_SCORE: 1.0757

RIG_SCORE: 0.7507

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R371H	TCGA-A6-6781	COAD	TCGA	EKENL	DEG_APCC_KENBOX_2	0.0556
p.R371H	DO8447	COAD	ICGC	EKENL	DEG_APCC_KENBOX_2	0.0556
p.R371C	TCGA-AP-A0LM	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.0556
p.R371C	TCGA-FI-A2D5	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.0556
p.R371C	DO43306	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.0556
p.R371C	DO41331	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.0556
p.E383D	TCGA-AX-A05Z	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.6758
p.E383D	DO40884	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.6758
p.E379Q	TCGA-C5-A8XK	CESC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.2778
p.E379Q	DO49904	CESC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.2778
p.D393E	TCGA-CC-A8HT	LIHC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.1111
p.D393E	DO52187	LIHC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.1111
p.E379K	TCGA-CV-7243	HNSC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.2778
p.E379K	DO15382	HNSC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.2778
p.S374F	TCGA-DU-6392	LGG	TCGA	EKENL	DEG_APCC_KENBOX_2	0.1389
p.S374F	DO22237	LGG	ICGC	EKENL	DEG_APCC_KENBOX_2	0.1389
p.S374Y	TCGA-KQ-A41N	BLCA	TCGA	EKENL	DEG_APCC_KENBOX_2	0.1389
p.S374Y	DO223588	BLCA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.1389
p.D393V	TCGA-XF-AAMX	BLCA	TCGA	EKENL	DEG_APCC_KENBOX_2	0.1111
p.D393V	DO51939	BLCA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.1111
p.N384K	DO228976	LICA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_APCC_KENBOX_2	4:8	EKENL	APC,CDC20,FZR1	0.7413	More...
P52179	Myomesin-1	DEG_APCC_KENBOX_2	128:132	EKENL	APC,CDC20,FZR1	0.9051	More...
Q3V6T2	Girdin	DEG_APCC_KENBOX_2	381:385	EKENL	APC,CDC20,FZR1	0.5571	More...
Q5VZM2	Ras-related GTP-binding protein B	DEG_APCC_KENBOX_2	11:15	EKENL	APC,CDC20,FZR1	0.8752	More...
Q71F23	Centromere protein U	DEG_APCC_KENBOX_2	196:200	EKENL	APC,CDC20,FZR1	0.9329	More...
Q8NEM0	Microcephalin	DEG_APCC_KENBOX_2	598:602	EKENL	APC,CDC20,FZR1	0.971	More...
Q9H0I2	Enkurin domain-containing protein 1	DEG_APCC_KENBOX_2	101:105	EKENL	APC,CDC20,FZR1	0.9868	More...
Q9UBT2	SUMO-activating enzyme subunit 2	DEG_APCC_KENBOX_2	616:620	EKENL	APC,CDC20,FZR1	0.9466	More...
Q9ULW0	Targeting protein for Xklp2	DEG_APCC_KENBOX_2	86:90	EKENL	APC,CDC20,FZR1	0.9952	More...
A6NNH2	Protein FAM90A27P	DEG_APCC_KENBOX_2	77:81	EKENL	APC,CDC20,FZR1	0.9811	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons