DegronMD - Q5VZM2(RRAGB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R374H	TCGA-32-2616	GBM	TCGA	LMR	DEG_APCC_TPR_1	372:374	Mutation altering degron motif	0.8244
p.E3K	TCGA-44-7670	LUAD	TCGA	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation rewiring degron network	0.1111
p.E3K	DO23555	LUAD	ICGC	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation rewiring degron network	0.1111
p.R374P	TCGA-69-7980	LUAD	TCGA	LMR	DEG_APCC_TPR_1	372:374	Mutation altering degron motif	0.7512
p.G366E	TCGA-AA-3715	COAD	TCGA	LMR	DEG_APCC_TPR_1	372:374	Mutation rewiring degron network	0.1667
p.R18I	TCGA-AP-A1E0	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation rewiring degron network	0.25
p.R18I	DO43154	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation rewiring degron network	0.25
p.N14Y	TCGA-B5-A1MW	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation altering degron motif	0.7059
p.N14Y	DO42913	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation altering degron motif	0.7059
p.D5N	TCGA-BQ-7051	KIRP	TCGA	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation rewiring degron network	0.1667
p.D5N	DO20778	KIRP	ICGC	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation rewiring degron network	0.1667
p.D365N	TCGA-FD-A3SO	BLCA	TCGA	LMR	DEG_APCC_TPR_1	372:374	Mutation rewiring degron network	0.1389
p.K12R	TCGA-FI-A2D5	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation altering degron motif	0.7237
p.K12R	DO41331	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation altering degron motif	0.7237
p.M19I	TCGA-YD-A89C	SKCM	TCGA	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation rewiring degron network	0.2222
p.M19I	DO219501	SKCM	ICGC	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation rewiring degron network	0.2222
p.M19I	SIDM00720	Mesothelioma	GDSC	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation rewiring degron network	0.2222
p.M19I	ACH-000648	Lung Cancer	CCLE	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation rewiring degron network	0.2222
p.M19I	NCI-H28	pleura	COSMIC	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation rewiring degron network	0.2222
p.D5H	DO223045	ESCA	ICGC	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation rewiring degron network	0.1667
p.R374C	SIDM00217	Colorectal Carcinoma	GDSC	LMR	DEG_APCC_TPR_1	372:374	Mutation altering degron motif	0.8301
p.R374C	SNU-1040	large intestine	COSMIC	LMR	DEG_APCC_TPR_1	372:374	Mutation altering degron motif	0.8301
p.S4F	SIDM01323	Oral Cavity Carcinoma	GDSC	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation blocking phosphorylation signal	0.5833
p.S4F	ACH-000732	Head and Neck Cancer	CCLE	EKENL	DEG_APCC_KENBOX_2	11:15	Mutation blocking phosphorylation signal	0.5833

Kaplan plot for RRAGB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RRAGB

UniProt ID: Q5VZM2

Entrez ID: 10325

Protein name: Ras-related GTP-binding protein B (Rag B) (RagB) (EC 3.6.5.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RRAGB in