DegronMD

Uniprot ID: Q5VZM2

Source protein: Ras-related GTP-binding protein B

Source gene: RRAGB

Class: DEG_APCC_TPR_1

Location: 372:374

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7903

ASA_SCORE: 123.9667

COIL: 0.7243

CONS_SCORE: 0.2183

DSS_SCORE: 0.8211

HELIX: 0.1467

FCONS_SCORE: 0.8034

RIG_SCORE: 0.8222

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R374H	TCGA-32-2616	GBM	TCGA	LMR	DEG_APCC_TPR_1	0.8244
p.R374P	TCGA-69-7980	LUAD	TCGA	LMR	DEG_APCC_TPR_1	0.7512
p.G366E	TCGA-AA-3715	COAD	TCGA	LMR	DEG_APCC_TPR_1	0.1667
p.D365N	TCGA-FD-A3SO	BLCA	TCGA	LMR	DEG_APCC_TPR_1	0.1389
p.R374C	SIDM00217	Colorectal Carcinoma	GDSC	LMR	DEG_APCC_TPR_1	0.8301
p.R374C	SNU-1040	large_intestine	COSMIC	LMR	DEG_APCC_TPR_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VZM2	Ras-related GTP-binding protein B	DEG_APCC_TPR_1	372:374	LMR	APC,CDC20,FZR1	0.7903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons