DegronMD

Uniprot ID: Q71F23

Source protein: Centromere protein U

Source gene: CENPU

Class: DEG_APCC_KENBOX_2

Location: 196:200

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9329

ASA_SCORE: 107.18

COIL: 0.37

CONS_SCORE: 0.4725

DSS_SCORE: 0.6224

HELIX: 0.6244

FCONS_SCORE: 1.0368

RIG_SCORE: 0.711

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E198D	TCGA-19-5956	GBM	TCGA	EKENL	DEG_APCC_KENBOX_2	0.6758
p.E198D	TCGA-EO-A22U	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.6758
p.L189I	TCGA-AX-A2HD	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.1389
p.S206L	TCGA-DA-A1I0	SKCM	TCGA	EKENL	DEG_APCC_KENBOX_2	0.6111
p.T208I	SIDM01695	Acute Myeloid Leukemia	GDSC	EKENL	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_APCC_KENBOX_2	4:8	EKENL	APC,CDC20,FZR1	0.7413	More...
P52179	Myomesin-1	DEG_APCC_KENBOX_2	128:132	EKENL	APC,CDC20,FZR1	0.9051	More...
Q3V6T2	Girdin	DEG_APCC_KENBOX_2	381:385	EKENL	APC,CDC20,FZR1	0.5571	More...
Q5VZM2	Ras-related GTP-binding protein B	DEG_APCC_KENBOX_2	11:15	EKENL	APC,CDC20,FZR1	0.8752	More...
Q71F23	Centromere protein U	DEG_APCC_KENBOX_2	196:200	EKENL	APC,CDC20,FZR1	0.9329	More...
Q8NEM0	Microcephalin	DEG_APCC_KENBOX_2	598:602	EKENL	APC,CDC20,FZR1	0.971	More...
Q9H0I2	Enkurin domain-containing protein 1	DEG_APCC_KENBOX_2	101:105	EKENL	APC,CDC20,FZR1	0.9868	More...
Q9UBT2	SUMO-activating enzyme subunit 2	DEG_APCC_KENBOX_2	616:620	EKENL	APC,CDC20,FZR1	0.9466	More...
Q9ULW0	Targeting protein for Xklp2	DEG_APCC_KENBOX_2	86:90	EKENL	APC,CDC20,FZR1	0.9952	More...
A6NNH2	Protein FAM90A27P	DEG_APCC_KENBOX_2	77:81	EKENL	APC,CDC20,FZR1	0.9811	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons