DegronMD

Uniprot ID: P52179

Source protein: Myomesin-1

Source gene: MYOM1

Class: DEG_SCF_FBW7_2

Location: 1163:1168

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 75.3

COIL: 0.869

CONS_SCORE: 0.4383

DSS_SCORE: 0.2846

HELIX: 0.021

FCONS_SCORE: 0.8066

RIG_SCORE: 0.7505

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1168Q	TCGA-67-3772	LUAD	TCGA	MTPKSE	DEG_SCF_FBW7_2	0.6744
p.F1169L	TCGA-AG-A002	READ	TCGA	MTPKSE	DEG_SCF_FBW7_2	0.3056
p.F1169L	TCGA-EO-A3AY	UCEC	TCGA	MTPKSE	DEG_SCF_FBW7_2	0.3056
p.D1174Y	TCGA-B5-A0K8	UCEC	TCGA	MTPKSE	DEG_SCF_FBW7_2	0.1667
p.D1174Y	TCGA-BK-A6W3	UCEC	TCGA	MTPKSE	DEG_SCF_FBW7_2	0.1667
p.P1165L	TCGA-BF-A5EQ	SKCM	TCGA	MTPKSE	DEG_SCF_FBW7_2	0.7582
p.E1168K	TCGA-BF-AAP2	SKCM	TCGA	MTPKSE	DEG_SCF_FBW7_2	0.7022
p.E1168K	SIDM01608	Endometrial Carcinoma	GDSC	MTPKSE	DEG_SCF_FBW7_2	0.7022
p.E1168K	ACH-000990	Endometrial/Uterine Cancer	CCLE	MTPKSE	DEG_SCF_FBW7_2	0.7022
p.S1155L	TCGA-CV-7411	HNSC	TCGA	MTPKSE	DEG_SCF_FBW7_2	0.1111
p.V1176A	TCGA-D1-A15X	UCEC	TCGA	MTPKSE	DEG_SCF_FBW7_2	0.1111
p.E1168G	TCGA-E6-A1LX	UCEC	TCGA	MTPKSE	DEG_SCF_FBW7_2	0.7199
p.D1174N	TCGA-EE-A29V	SKCM	TCGA	MTPKSE	DEG_SCF_FBW7_2	0.1667
p.S1167Y	TCGA-VQ-A8P2	STAD	TCGA	MTPKSE	DEG_SCF_FBW7_2	0.6009
p.R1165Q	DO219733	CESC	ICGC	MTPKSE	DEG_SCF_FBW7_2	0.7329
p.A1155V	DO13522	GBM	ICGC	MTPKSE	DEG_SCF_FBW7_2	0.1111
p.L1154S	DO51761	STAD	ICGC	MTPKSE	DEG_SCF_FBW7_2	0.0833
p.G1162S	DO40954	UCEC	ICGC	MTPKSE	DEG_SCF_FBW7_2	0.3056
p.G1162S	DO52421	UCEC	ICGC	MTPKSE	DEG_SCF_FBW7_2	0.3056
p.P1165S	SIDM01034	B-Lymphoblastic Leukemia	GDSC	MTPKSE	DEG_SCF_FBW7_2	0.6752
p.P1165S	SIDM00466	Ovarian Carcinoma	GDSC	MTPKSE	DEG_SCF_FBW7_2	0.6752
p.P1165S	SIDM00351	Oral Cavity Carcinoma	GDSC	MTPKSE	DEG_SCF_FBW7_2	0.6752
p.P1165S	SIDM01172	Acute Myeloid Leukemia	GDSC	MTPKSE	DEG_SCF_FBW7_2	0.6752
p.P1165S	SIDM01451	Pancreatic Carcinoma	GDSC	MTPKSE	DEG_SCF_FBW7_2	0.6752
p.P1165S	SIDM00159	Biliary Tract Carcinoma	GDSC	MTPKSE	DEG_SCF_FBW7_2	0.6752
p.W1171L	SIDM00466	Ovarian Carcinoma	GDSC	MTPKSE	DEG_SCF_FBW7_2	0.25
p.W1171L	ACH-000443	Ovarian Cancer	CCLE	MTPKSE	DEG_SCF_FBW7_2	0.25
p.W1171L	OVKATE	ovary	COSMIC	MTPKSE	DEG_SCF_FBW7_2	0.25
p.S1170A	ACH-001970	Metastasis	CCLE	MTPKSE	DEG_SCF_FBW7_2	0.7222
p.Y1159C	GP5d	large_intestine	COSMIC	MTPKSE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MTPKSE

Degron related mutations and impact score

Drug responses associated with MYOM1 mutations

All proteins holding degron of MTPKSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52179	Myomesin-1	DEG_SCF_FBW7_2	1163:1168	MTPKSE	FBXW7	0.9956	More...