DegronMD

Uniprot ID: P52179

Source protein: Myomesin-1

Source gene: MYOM1

Class: DEG_APCC_KENBOX_2

Location: 290:294

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6123

ASA_SCORE: 76.76

COIL: 0.631

CONS_SCORE: 0.6792

DSS_SCORE: 0.2189

HELIX: 0.0048

FCONS_SCORE: 0.936

RIG_SCORE: 0.8299

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W303C	TCGA-A5-A0G1	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	0.0833
p.W303C	DO42472	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.0833
p.A301S	TCGA-A5-A0G1	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	0.1389
p.A301S	DO42472	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.1389
p.V288A	TCGA-AX-A2HJ	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	0.2778
p.V288A	DO42105	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.2778
p.E292D	TCGA-D1-A17Q	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	0.6758
p.E292D	DO41903	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.6758
p.G302D	TCGA-E9-A1R4	BRCA	TCGA	EKENV	DEG_APCC_KENBOX_2	0.1111
p.G302D	DO5815	BRCA	ICGC	EKENV	DEG_APCC_KENBOX_2	0.1111
p.L296V	TCGA-EO-A22R	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	0.2778
p.L296V	DO42713	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.2778
p.R284C	TCGA-EY-A5W2	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	0.1667
p.R284C	DO48177	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.1667
p.I300V	TCGA-O2-A52N	LUSC	TCGA	EKENV	DEG_APCC_KENBOX_2	0.1667
p.I300V	DO219217	LUSC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.1667
p.H297L	DO233140	GACA	ICGC	EKENV	DEG_APCC_KENBOX_2	0.25
p.T287K	DO231049	LUSC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.25
p.P296S	EN	endometrium	COSMIC	EKENV	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75152	Zinc finger CCCH domain-containing protein 11A	DEG_APCC_KENBOX_2	253:257	EKENV	APC,CDC20,FZR1	0.9975	More...
P52179	Myomesin-1	DEG_APCC_KENBOX_2	290:294	EKENV	APC,CDC20,FZR1	0.6123	More...
Q5VWN6	Protein TASOR 2	DEG_APCC_KENBOX_2	1450:1454	EKENV	APC,CDC20,FZR1	0.753	More...
Q86XI2	Condensin-2 complex subunit G2	DEG_APCC_KENBOX_2	600:604	EKENV	APC,CDC20,FZR1	0.6924	More...
Q8TDB4	Protein MGARP	DEG_APCC_KENBOX_2	95:99	EKENV	APC,CDC20,FZR1	0.8967	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_APCC_KENBOX_2	1130:1134	EKENV	APC,CDC20,FZR1	0.8157	More...
Q5TZJ5	Spermatogenesis-associated protein 31A1	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9969	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9054	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9543	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9667	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9511	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons