DegronMD - O75152(ZC3H11A)

FUNCTION: RNA-binding protein that interacts with purine-rich sequences and is involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA Export. {ECO:0000269|PubMed:29610341}.

GO - Biological processes (BP): poly(A)+ mRNA export from nucleus [GO:0016973]

GO - Molecular function (MF): metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]

GO - Cellular component (CC): nucleoplasm [GO:0005654]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S687N	DO222843	MELA	ICGC	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation altering degron motif	0.818
p.S687G	ACH-000676	Brain Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation altering degron motif	0.8104
p.S687G	ACH-002389	Neuroblastoma	CCLE	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation altering degron motif	0.8104
p.S687G	ACN	autonomic ganglia	COSMIC	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation altering degron motif	0.8104
p.S713L	ACH-001203	Lymphoma	CCLE	SEDKSVTVPEA	DEG_COP1_1	709:719	Mutation altering degron motif	0.7667
p.S713L	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	SEDKSVTVPEA	DEG_COP1_1	709:719	Mutation altering degron motif	0.7667
p.T151K	DO228945	LICA	ICGC	ESSENVPSP	DEG_COP1_1	142:150	Mutation blocking phosphorylation signal	0.75
p.A719T	TCGA-BR-8680	STAD	TCGA	SEDKSVTVPEA	DEG_COP1_1	709:719	Mutation altering degron motif	0.7139
p.A719T	DO47769	STAD	ICGC	SEDKSVTVPEA	DEG_COP1_1	709:719	Mutation altering degron motif	0.7139
p.A395T	DO48200	ESCA	ICGC	ARSSS	DEG_SPOP_SBC_1	395:399	Mutation altering degron motif	0.7139
p.V147F	DO228971	LICA	ICGC	ESSENVPSP	DEG_COP1_1	142:150	Mutation altering degron motif	0.7068
p.P685T	DO34200	PACA	ICGC	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation altering degron motif	0.7031
p.K324E	TCGA-DU-7015	LGG	TCGA	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	317:324	Mutation altering degron motif	0.7022
p.K324E	DO22619	LGG	ICGC	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	317:324	Mutation altering degron motif	0.7022
p.P685S	DO231810	LINC	ICGC	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation altering degron motif	0.6752
p.P148S	DO222546	MELA	ICGC	ESSENVPSP	DEG_COP1_1	142:150	Mutation altering degron motif	0.6752
p.S391F	TCGA-05-4424	LUAD	TCGA	ARSSS	DEG_SPOP_SBC_1	395:399	Mutation blocking phosphorylation signal	0.6667
p.S391F	DO23672	LUAD	ICGC	ARSSS	DEG_SPOP_SBC_1	395:399	Mutation blocking phosphorylation signal	0.6667
p.E145K	TCGA-E6-A1LX	UCEC	TCGA	ESSENVPSP	DEG_COP1_1	142:150	Mutation altering degron motif	0.591
p.E145K	DO41020	UCEC	ICGC	ESSENVPSP	DEG_COP1_1	142:150	Mutation altering degron motif	0.591

Showing 1 to 20 of 80 entries

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Kaplan plot for ZC3H11A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZC3H11A

UniProt ID: O75152

Entrez ID: 9877

Protein name: Zinc finger CCCH domain-containing protein 11A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZC3H11A in