DegronMD - O75152(ZC3H11A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S391F	TCGA-05-4424	LUAD	TCGA	ARSSS	DEG_SPOP_SBC_1	395:399	Mutation blocking phosphorylation signal	0.6667
p.S391F	DO23672	LUAD	ICGC	ARSSS	DEG_SPOP_SBC_1	395:399	Mutation blocking phosphorylation signal	0.6667
p.K332N	TCGA-17-Z031	LUAD	TCGA	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	317:324	Mutation blocking ubiquitination signal	0.5556
p.A159P	TCGA-17-Z051	LUAD	TCGA	ESSENVPSP	DEG_COP1_1	142:150	Mutation rewiring degron network	0.0833
p.E333V	TCGA-18-3421	LUSC	TCGA	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	317:324	Mutation rewiring degron network	0.0833
p.E333V	DO27652	LUSC	ICGC	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	317:324	Mutation rewiring degron network	0.0833
p.S393L	TCGA-85-8276	LUSC	TCGA	ARSSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.2778
p.S393L	DO26436	LUSC	ICGC	ARSSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.2778
p.S330F	TCGA-86-A4JF	LUAD	TCGA	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	317:324	Mutation rewiring degron network	0.1667
p.S330F	DO45317	LUAD	ICGC	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	317:324	Mutation rewiring degron network	0.1667
p.R402H	TCGA-AD-A5EJ	COAD	TCGA	ARSSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.25
p.R402H	DO50090	COAD	ICGC	ARSSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.25
p.K323N	TCGA-AG-A002	READ	TCGA	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	317:324	Mutation altering degron motif	0.5806
p.R262M	TCGA-AP-A051	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	253:257	Mutation rewiring degron network	0.1944
p.R262M	DO42673	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	253:257	Mutation rewiring degron network	0.1944
p.A160T	TCGA-AP-A0LE	UCEC	TCGA	ESSENVPSP	DEG_COP1_1	142:150	Mutation rewiring degron network	0.0556
p.A160T	DO43418	UCEC	ICGC	ESSENVPSP	DEG_COP1_1	142:150	Mutation rewiring degron network	0.0556
p.P706L	TCGA-AX-A2HA	UCEC	TCGA	SEDKSVTVPEA	DEG_COP1_1	709:719	Mutation rewiring degron network	0.25
p.P706L	DO42504	UCEC	ICGC	SEDKSVTVPEA	DEG_COP1_1	709:719	Mutation rewiring degron network	0.25
p.M139V	TCGA-BG-A222	UCEC	TCGA	ESSENVPSP	DEG_COP1_1	142:150	Mutation rewiring degron network	0.25
p.M139V	DO42977	UCEC	ICGC	ESSENVPSP	DEG_COP1_1	142:150	Mutation rewiring degron network	0.25
p.M139V	ACH-000705	Lung Cancer	CCLE	ESSENVPSP	DEG_COP1_1	142:150	Mutation rewiring degron network	0.25
p.M139V	ACH-001113	Lung Cancer	CCLE	ESSENVPSP	DEG_COP1_1	142:150	Mutation rewiring degron network	0.25
p.M139V	LC-1-sq	lung	COSMIC	ESSENVPSP	DEG_COP1_1	142:150	Mutation rewiring degron network	0.25
p.K320N	TCGA-BR-8680	STAD	TCGA	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	317:324	Mutation altering degron motif	0.5806
p.K320N	DO47769	STAD	ICGC	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	317:324	Mutation altering degron motif	0.5806
p.A719T	TCGA-BR-8680	STAD	TCGA	SEDKSVTVPEA	DEG_COP1_1	709:719	Mutation altering degron motif	0.7139
p.A719T	DO47769	STAD	ICGC	SEDKSVTVPEA	DEG_COP1_1	709:719	Mutation altering degron motif	0.7139
p.A678V	TCGA-CG-4442	STAD	TCGA	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation rewiring degron network	0.1389
p.A678V	TCGA-N7-A4Y0	UCS	TCGA	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation rewiring degron network	0.1389
p.A678V	DO38380	STAD	ICGC	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation rewiring degron network	0.1389
p.G233C	TCGA-DF-A2KN	UCEC	TCGA	LLLHPE	LIG_APCC_ABBA_1	242:247	Mutation rewiring degron network	0.0833
p.G233C	DO223282	UCEC	ICGC	LLLHPE	LIG_APCC_ABBA_1	242:247	Mutation rewiring degron network	0.0833
p.V138I	TCGA-DU-6392	LGG	TCGA	ESSENVPSP	DEG_COP1_1	142:150	Mutation rewiring degron network	0.2222
p.V138I	DO22237	LGG	ICGC	ESSENVPSP	DEG_COP1_1	142:150	Mutation rewiring degron network	0.2222
p.K324E	TCGA-DU-7015	LGG	TCGA	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	317:324	Mutation altering degron motif	0.7022
p.K324E	DO22619	LGG	ICGC	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	317:324	Mutation altering degron motif	0.7022
p.E145K	TCGA-E6-A1LX	UCEC	TCGA	ESSENVPSP	DEG_COP1_1	142:150	Mutation altering degron motif	0.591
p.E145K	DO41020	UCEC	ICGC	ESSENVPSP	DEG_COP1_1	142:150	Mutation altering degron motif	0.591
p.S267F	TCGA-EE-A2GC	SKCM	TCGA	EKENV	DEG_APCC_KENBOX_2	253:257	Mutation rewiring degron network	0.0556
p.S267F	DO37839	SKCM	ICGC	EKENV	DEG_APCC_KENBOX_2	253:257	Mutation rewiring degron network	0.0556
p.P722S	TCGA-FR-A726	SKCM	TCGA	SEDKSVTVPEA	DEG_COP1_1	709:719	Mutation rewiring degron network	0.25
p.P722S	DO48665	SKCM	ICGC	SEDKSVTVPEA	DEG_COP1_1	709:719	Mutation rewiring degron network	0.25
p.R258M	TCGA-FS-A1Z4	SKCM	TCGA	EKENV	DEG_APCC_KENBOX_2	253:257	Mutation rewiring degron network	0.3056
p.R258M	TCGA-GN-A265	SKCM	TCGA	EKENV	DEG_APCC_KENBOX_2	253:257	Mutation rewiring degron network	0.3056
p.R258M	DO37491	SKCM	ICGC	EKENV	DEG_APCC_KENBOX_2	253:257	Mutation rewiring degron network	0.3056
p.R258M	DO37462	SKCM	ICGC	EKENV	DEG_APCC_KENBOX_2	253:257	Mutation rewiring degron network	0.3056
p.A395T	DO48200	ESCA	ICGC	ARSSS	DEG_SPOP_SBC_1	395:399	Mutation altering degron motif	0.7139
p.R136Q	DO233732	GACA	ICGC	ESSENVPSP	DEG_COP1_1	142:150	Mutation rewiring degron network	0.1667
p.T151K	DO228945	LICA	ICGC	ESSENVPSP	DEG_COP1_1	142:150	Mutation blocking phosphorylation signal	0.75
p.E234D	DO228948	LICA	ICGC	LLLHPE	LIG_APCC_ABBA_1	242:247	Mutation rewiring degron network	0.1111
p.V147F	DO228971	LICA	ICGC	ESSENVPSP	DEG_COP1_1	142:150	Mutation altering degron motif	0.7068
p.V691F	DO229022	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation rewiring degron network	0.2778
p.V138F	DO229026	LICA	ICGC	ESSENVPSP	DEG_COP1_1	142:150	Mutation rewiring degron network	0.2222
p.G235S	DO50970	LICA	ICGC	LLLHPE	LIG_APCC_ABBA_1	242:247	Mutation rewiring degron network	0.1389
p.T263A	DO23152	LINC	ICGC	EKENV	DEG_APCC_KENBOX_2	253:257	Mutation rewiring degron network	0.1667
p.T263A	DO45081	LINC	ICGC	EKENV	DEG_APCC_KENBOX_2	253:257	Mutation rewiring degron network	0.1667
p.P685S	DO231810	LINC	ICGC	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation altering degron motif	0.6752
p.G233V	DO220898	MELA	ICGC	LLLHPE	LIG_APCC_ABBA_1	242:247	Mutation rewiring degron network	0.0833
p.P133T	DO222363	MELA	ICGC	ESSENVPSP	DEG_COP1_1	142:150	Mutation rewiring degron network	0.0833
p.P148S	DO222546	MELA	ICGC	ESSENVPSP	DEG_COP1_1	142:150	Mutation altering degron motif	0.6752
p.S687N	DO222843	MELA	ICGC	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation altering degron motif	0.818
p.P685T	DO34200	PACA	ICGC	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation altering degron motif	0.7031
p.R136W	DO228138	PBCA	ICGC	ESSENVPSP	DEG_COP1_1	142:150	Mutation rewiring degron network	0.1667
p.A682P	ACH-000367	Lung Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation rewiring degron network	0.25
p.A682P	NCI-H226	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation rewiring degron network	0.25
p.S687G	ACH-000676	Brain Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation altering degron motif	0.8104
p.S687G	ACH-002389	Neuroblastoma	CCLE	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation altering degron motif	0.8104
p.S687G	ACN	autonomic ganglia	COSMIC	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation altering degron motif	0.8104
p.S713L	ACH-001203	Lymphoma	CCLE	SEDKSVTVPEA	DEG_COP1_1	709:719	Mutation altering degron motif	0.7667
p.S713L	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	SEDKSVTVPEA	DEG_COP1_1	709:719	Mutation altering degron motif	0.7667
p.A682S	ACH-001358	Breast Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation rewiring degron network	0.25
p.A682S	MDA-MB-330	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	685:689	Mutation rewiring degron network	0.25
p.L266V	ACH-001374	Ovarian Cancer	CCLE	EKENV	DEG_APCC_KENBOX_2	253:257	Mutation rewiring degron network	0.0833
p.L266V	PA-1	ovary	COSMIC	EKENV	DEG_APCC_KENBOX_2	253:257	Mutation rewiring degron network	0.0833
p.R723T	ACH-001416	Bladder Cancer	CCLE	SEDKSVTVPEA	DEG_COP1_1	709:719	Mutation rewiring degron network	0.2222
p.E408Q	ACH-001618	Leukemia	CCLE	ARSSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.0833
p.N721I	ACH-002266	Bladder Cancer	CCLE	SEDKSVTVPEA	DEG_COP1_1	709:719	Mutation rewiring degron network	0.2778
p.N721I	LB831-BLC	urinary tract	COSMIC	SEDKSVTVPEA	DEG_COP1_1	709:719	Mutation rewiring degron network	0.2778
p.R402C	ACH-002509	Skin Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZC3H11A

UniProt ID: O75152

Entrez ID: 9877

Protein name: Zinc finger CCCH domain-containing protein 11A

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZC3H11A in