DegronMD

Uniprot ID: O75152

Source protein: Zinc finger CCCH domain-containing protein 11A

Source gene: ZC3H11A

Class: DEG_COP1_1

Location: 142:150

E3 ligase: COP1

DEGRON score: 0.9097

ASA_SCORE: 95.6444

COIL: 0.9282

CONS_SCORE: 0.769

DSS_SCORE: 0.6815

HELIX: 0.0298

FCONS_SCORE: 0.9473

RIG_SCORE: 0.5583

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A159P	TCGA-17-Z051	LUAD	TCGA	ESSENVPSP	DEG_COP1_1	0.0833
p.A160T	TCGA-AP-A0LE	UCEC	TCGA	ESSENVPSP	DEG_COP1_1	0.0556
p.A160T	DO43418	UCEC	ICGC	ESSENVPSP	DEG_COP1_1	0.0556
p.M139V	TCGA-BG-A222	UCEC	TCGA	ESSENVPSP	DEG_COP1_1	0.25
p.M139V	DO42977	UCEC	ICGC	ESSENVPSP	DEG_COP1_1	0.25
p.M139V	ACH-000705	Lung Cancer	CCLE	ESSENVPSP	DEG_COP1_1	0.25
p.M139V	ACH-001113	Lung Cancer	CCLE	ESSENVPSP	DEG_COP1_1	0.25
p.M139V	LC-1-sq	lung	COSMIC	ESSENVPSP	DEG_COP1_1	0.25
p.V138I	TCGA-DU-6392	LGG	TCGA	ESSENVPSP	DEG_COP1_1	0.2222
p.V138I	DO22237	LGG	ICGC	ESSENVPSP	DEG_COP1_1	0.2222
p.E145K	TCGA-E6-A1LX	UCEC	TCGA	ESSENVPSP	DEG_COP1_1	0.591
p.E145K	DO41020	UCEC	ICGC	ESSENVPSP	DEG_COP1_1	0.591
p.R136Q	DO233732	GACA	ICGC	ESSENVPSP	DEG_COP1_1	0.1667
p.T151K	DO228945	LICA	ICGC	ESSENVPSP	DEG_COP1_1	0.75
p.V147F	DO228971	LICA	ICGC	ESSENVPSP	DEG_COP1_1	0.7068
p.V138F	DO229026	LICA	ICGC	ESSENVPSP	DEG_COP1_1	0.2222
p.P133T	DO222363	MELA	ICGC	ESSENVPSP	DEG_COP1_1	0.0833
p.P148S	DO222546	MELA	ICGC	ESSENVPSP	DEG_COP1_1	0.6752
p.R136W	DO228138	PBCA	ICGC	ESSENVPSP	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75152	Zinc finger CCCH domain-containing protein 11A	DEG_COP1_1	142:150	ESSENVPSP	COP1	0.9097	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons