DegronMD

Uniprot ID: O75152

Source protein: Zinc finger CCCH domain-containing protein 11A

Source gene: ZC3H11A

Class: DEG_COP1_1

Location: 709:719

E3 ligase: COP1

DEGRON score: 0.8679

ASA_SCORE: 97.1545

COIL: 0.8758

CONS_SCORE: 0.4582

DSS_SCORE: 0.4863

HELIX: 0.0565

FCONS_SCORE: 0.9032

RIG_SCORE: 0.7138

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P706L	TCGA-AX-A2HA	UCEC	TCGA	SEDKSVTVPEA	DEG_COP1_1	0.25
p.P706L	DO42504	UCEC	ICGC	SEDKSVTVPEA	DEG_COP1_1	0.25
p.A719T	TCGA-BR-8680	STAD	TCGA	SEDKSVTVPEA	DEG_COP1_1	0.7139
p.A719T	DO47769	STAD	ICGC	SEDKSVTVPEA	DEG_COP1_1	0.7139
p.P722S	TCGA-FR-A726	SKCM	TCGA	SEDKSVTVPEA	DEG_COP1_1	0.25
p.P722S	DO48665	SKCM	ICGC	SEDKSVTVPEA	DEG_COP1_1	0.25
p.S713L	ACH-001203	Lymphoma	CCLE	SEDKSVTVPEA	DEG_COP1_1	0.7667
p.S713L	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	SEDKSVTVPEA	DEG_COP1_1	0.7667
p.R723T	ACH-001416	Bladder Cancer	CCLE	SEDKSVTVPEA	DEG_COP1_1	0.2222
p.N721I	ACH-002266	Bladder Cancer	CCLE	SEDKSVTVPEA	DEG_COP1_1	0.2778
p.N721I	LB831-BLC	urinary_tract	COSMIC	SEDKSVTVPEA	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75152	Zinc finger CCCH domain-containing protein 11A	DEG_COP1_1	709:719	SEDKSVTVPEA	COP1	0.8679	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons