DegronMD

Uniprot ID: O75152

Source protein: Zinc finger CCCH domain-containing protein 11A

Source gene: ZC3H11A

Class: DEG_SCF_SKP2-CKS1_1

Location: 317:324

E3 ligase: SKP2,CSK1

DEGRON score: 0.984

ASA_SCORE: 109.6375

COIL: 0.8996

CONS_SCORE: 0.4402

DSS_SCORE: 0.6253

HELIX: 0.0605

FCONS_SCORE: 0.855

RIG_SCORE: 0.7063

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K332N	TCGA-17-Z031	LUAD	TCGA	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	0.5556
p.E333V	TCGA-18-3421	LUSC	TCGA	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	0.0833
p.E333V	DO27652	LUSC	ICGC	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	0.0833
p.S330F	TCGA-86-A4JF	LUAD	TCGA	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	0.1667
p.S330F	DO45317	LUAD	ICGC	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	0.1667
p.K323N	TCGA-AG-A002	READ	TCGA	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	0.5806
p.K320N	TCGA-BR-8680	STAD	TCGA	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	0.5806
p.K320N	DO47769	STAD	ICGC	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	0.5806
p.K324E	TCGA-DU-7015	LGG	TCGA	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	0.7022
p.K324E	DO22619	LGG	ICGC	NIDKTPKK	DEG_SCF_SKP2-CKS1_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75152	Zinc finger CCCH domain-containing protein 11A	DEG_SCF_SKP2-CKS1_1	317:324	NIDKTPKK	SKP2,CSK1	0.984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons