DegronMD

Uniprot ID: O75152

Source protein: Zinc finger CCCH domain-containing protein 11A

Source gene: ZC3H11A

Class: LIG_APCC_ABBA_1

Location: 242:247

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9024

ASA_SCORE: 98.9

COIL: 0.906

CONS_SCORE: 0.4041

DSS_SCORE: 0.6677

HELIX: 0.0315

FCONS_SCORE: 0.7424

RIG_SCORE: 0.6588

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G233C	TCGA-DF-A2KN	UCEC	TCGA	LLLHPE	LIG_APCC_ABBA_1	0.0833
p.G233C	DO223282	UCEC	ICGC	LLLHPE	LIG_APCC_ABBA_1	0.0833
p.E234D	DO228948	LICA	ICGC	LLLHPE	LIG_APCC_ABBA_1	0.1111
p.G235S	DO50970	LICA	ICGC	LLLHPE	LIG_APCC_ABBA_1	0.1389
p.G233V	DO220898	MELA	ICGC	LLLHPE	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75152	Zinc finger CCCH domain-containing protein 11A	LIG_APCC_ABBA_1	242:247	LLLHPE	APC,CDC20,FZR1	0.9024	More...
Q9BVC5	Ashwin	LIG_APCC_ABBA_1	15:20	LLLHPE	APC,CDC20,FZR1	0.9216	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons