DegronMD

Uniprot ID: Q9BVC5

Source protein: Ashwin

Source gene: C2orf49

Class: LIG_APCC_ABBA_1

Location: 15:20

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9216

ASA_SCORE: 51.8167

COIL: 0.4645

CONS_SCORE: 0.9515

DSS_SCORE: 0.1761

HELIX: 0.5062

FCONS_SCORE: 1.2826

RIG_SCORE: 0.8387

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G7C	TCGA-43-5668	LUSC	TCGA	LLLHPE	LIG_APCC_ABBA_1	0.1111
p.R8H	TCGA-DK-A3WW	BLCA	TCGA	LLLHPE	LIG_APCC_ABBA_1	0.1389
p.S9N	TCGA-EY-A549	UCEC	TCGA	LLLHPE	LIG_APCC_ABBA_1	0.1667
p.R8C	TCGA-NH-A5IV	COAD	TCGA	LLLHPE	LIG_APCC_ABBA_1	0.1389
p.R24C	DO220881	MELA	ICGC	LLLHPE	LIG_APCC_ABBA_1	0.2222
p.R24C	DO222775	MELA	ICGC	LLLHPE	LIG_APCC_ABBA_1	0.2222
p.R24C	DO222875	MELA	ICGC	LLLHPE	LIG_APCC_ABBA_1	0.2222
p.G7R	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	LLLHPE	LIG_APCC_ABBA_1	0.1111
p.G7R	ACH-000826	Lung Cancer	CCLE	LLLHPE	LIG_APCC_ABBA_1	0.1111
p.T30A	SIDM00561	Other Blood Cancers	GDSC	LLLHPE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75152	Zinc finger CCCH domain-containing protein 11A	LIG_APCC_ABBA_1	242:247	LLLHPE	APC,CDC20,FZR1	0.9024	More...
Q9BVC5	Ashwin	LIG_APCC_ABBA_1	15:20	LLLHPE	APC,CDC20,FZR1	0.9216	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons