DegronMD - Q9BVC5(C2orf49)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G7C	TCGA-43-5668	LUSC	TCGA	LLLHPE	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.1111
p.R8H	TCGA-DK-A3WW	BLCA	TCGA	LLLHPE	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.1389
p.S9N	TCGA-EY-A549	UCEC	TCGA	LLLHPE	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.1667
p.R8C	TCGA-NH-A5IV	COAD	TCGA	LLLHPE	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.1389
p.R24C	DO220881	MELA	ICGC	LLLHPE	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.2222
p.R24C	DO222775	MELA	ICGC	LLLHPE	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.2222
p.R24C	DO222875	MELA	ICGC	LLLHPE	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.2222
p.G7R	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	LLLHPE	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.1111
p.G7R	ACH-000826	Lung Cancer	CCLE	LLLHPE	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.1111
p.T30A	SIDM00561	Other Blood Cancers	GDSC	LLLHPE	LIG_APCC_ABBA_1	15:20	Mutation rewiring degron network	0.0556

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons