DegronMD

Uniprot ID: O75152

Source protein: Zinc finger CCCH domain-containing protein 11A

Source gene: ZC3H11A

Class: DEG_APCC_KENBOX_2

Location: 253:257

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9975

ASA_SCORE: 104.36

COIL: 0.7734

CONS_SCORE: 0.7593

DSS_SCORE: 0.5669

HELIX: 0.1606

FCONS_SCORE: 1.4965

RIG_SCORE: 0.6823

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R262M	TCGA-AP-A051	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	0.1944
p.R262M	DO42673	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.S267F	TCGA-EE-A2GC	SKCM	TCGA	EKENV	DEG_APCC_KENBOX_2	0.0556
p.S267F	DO37839	SKCM	ICGC	EKENV	DEG_APCC_KENBOX_2	0.0556
p.R258M	TCGA-FS-A1Z4	SKCM	TCGA	EKENV	DEG_APCC_KENBOX_2	0.3056
p.R258M	TCGA-GN-A265	SKCM	TCGA	EKENV	DEG_APCC_KENBOX_2	0.3056
p.R258M	DO37491	SKCM	ICGC	EKENV	DEG_APCC_KENBOX_2	0.3056
p.R258M	DO37462	SKCM	ICGC	EKENV	DEG_APCC_KENBOX_2	0.3056
p.T263A	DO23152	LINC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.1667
p.T263A	DO45081	LINC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.1667
p.L266V	ACH-001374	Ovarian Cancer	CCLE	EKENV	DEG_APCC_KENBOX_2	0.0833
p.L266V	PA-1	ovary	COSMIC	EKENV	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75152	Zinc finger CCCH domain-containing protein 11A	DEG_APCC_KENBOX_2	253:257	EKENV	APC,CDC20,FZR1	0.9975	More...
P52179	Myomesin-1	DEG_APCC_KENBOX_2	290:294	EKENV	APC,CDC20,FZR1	0.6123	More...
Q5VWN6	Protein TASOR 2	DEG_APCC_KENBOX_2	1450:1454	EKENV	APC,CDC20,FZR1	0.753	More...
Q86XI2	Condensin-2 complex subunit G2	DEG_APCC_KENBOX_2	600:604	EKENV	APC,CDC20,FZR1	0.6924	More...
Q8TDB4	Protein MGARP	DEG_APCC_KENBOX_2	95:99	EKENV	APC,CDC20,FZR1	0.8967	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_APCC_KENBOX_2	1130:1134	EKENV	APC,CDC20,FZR1	0.8157	More...
Q5TZJ5	Spermatogenesis-associated protein 31A1	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9969	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9054	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9543	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9667	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9511	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons