DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
EKENV
Uniprot ID:
O75152
Source protein:
Zinc finger CCCH domain-containing protein 11A
Source gene:
ZC3H11A
Class:
DEG_APCC_KENBOX_2
Location:
253:257
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9975
ASA_SCORE:
104.36
COIL:
0.7734
CONS_SCORE:
0.7593
DSS_SCORE:
0.5669
HELIX:
0.1606
FCONS_SCORE:
1.4965
RIG_SCORE:
0.6823
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R258M
TCGA-FS-A1Z4
SKCM
TCGA
EKENV
DEG_APCC_KENBOX_2
0.3056
p.R258M
TCGA-GN-A265
SKCM
TCGA
EKENV
DEG_APCC_KENBOX_2
0.3056
p.R258M
DO37491
SKCM
ICGC
EKENV
DEG_APCC_KENBOX_2
0.3056
p.R258M
DO37462
SKCM
ICGC
EKENV
DEG_APCC_KENBOX_2
0.3056
p.R262M
TCGA-AP-A051
UCEC
TCGA
EKENV
DEG_APCC_KENBOX_2
0.1944
p.R262M
DO42673
UCEC
ICGC
EKENV
DEG_APCC_KENBOX_2
0.1944
p.T263A
DO23152
LINC
ICGC
EKENV
DEG_APCC_KENBOX_2
0.1667
p.T263A
DO45081
LINC
ICGC
EKENV
DEG_APCC_KENBOX_2
0.1667
p.L266V
ACH-001374
Ovarian Cancer
CCLE
EKENV
DEG_APCC_KENBOX_2
0.0833
p.L266V
PA-1
ovary
COSMIC
EKENV
DEG_APCC_KENBOX_2
0.0833
p.S267F
TCGA-EE-A2GC
SKCM
TCGA
EKENV
DEG_APCC_KENBOX_2
0.0556
p.S267F
DO37839
SKCM
ICGC
EKENV
DEG_APCC_KENBOX_2
0.0556
Showing 1 to 12 of 12 entries
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Drug responses associated with ZC3H11A mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of EKENV
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9C0D2
Centrosomal protein of 295 kDa
DEG_APCC_KENBOX_2
1130:1134
EKENV
APC,CDC20,FZR1
0.8157
More...
Q86XI2
Condensin-2 complex subunit G2
DEG_APCC_KENBOX_2
600:604
EKENV
APC,CDC20,FZR1
0.6924
More...
P52179
Myomesin-1
DEG_APCC_KENBOX_2
290:294
EKENV
APC,CDC20,FZR1
0.6123
More...
Q8TDB4
Protein MGARP
DEG_APCC_KENBOX_2
95:99
EKENV
APC,CDC20,FZR1
0.8967
More...
Q5VWN6
Protein TASOR 2
DEG_APCC_KENBOX_2
1450:1454
EKENV
APC,CDC20,FZR1
0.753
More...
Q5TZJ5
Spermatogenesis-associated protein 31A1
DEG_APCC_KENBOX_2
343:347
EKENV
APC,CDC20,FZR1
0.9969
More...
Q5VYP0
Spermatogenesis-associated protein 31A3
DEG_APCC_KENBOX_2
343:347
EKENV
APC,CDC20,FZR1
0.9511
More...
Q5VU36
Spermatogenesis-associated protein 31A5
DEG_APCC_KENBOX_2
343:347
EKENV
APC,CDC20,FZR1
0.9543
More...
Q5VVP1
Spermatogenesis-associated protein 31A6
DEG_APCC_KENBOX_2
343:347
EKENV
APC,CDC20,FZR1
0.9667
More...
Q8IWB4
Spermatogenesis-associated protein 31A7
DEG_APCC_KENBOX_2
343:347
EKENV
APC,CDC20,FZR1
0.9054
More...
O75152
Zinc finger CCCH domain-containing protein 11A
DEG_APCC_KENBOX_2
253:257
EKENV
APC,CDC20,FZR1
0.9975
More...
Showing 1 to 11 of 11 entries
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