DegronMD - Q5VVP1(SPATA31A6)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1125G	TCGA-06-5416	GBM	TCGA	LRTPQLT	DEG_SCF_FBW7_1	1124:1130	Mutation altering degron motif	0.6457
p.R1125G	DO10880	GBM	ICGC	LRTPQLT	DEG_SCF_FBW7_1	1124:1130	Mutation altering degron motif	0.6457
p.T1207K	TCGA-17-Z061	LUAD	TCGA	VYSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.1111
p.S95L	TCGA-32-4210	GBM	TCGA	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.S95L	TCGA-74-6581	GBM	TCGA	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.S95L	TCGA-EE-A2MD	SKCM	TCGA	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.S95L	DO11645	GBM	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.S95L	DO11531	GBM	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.S95L	DO222434	MELA	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.S95L	DO37851	SKCM	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.Q653L	TCGA-44-7662	LUAD	TCGA	STSTGE	DEG_Kelch_Keap1_1	642:647	Mutation rewiring degron network	0.1667
p.Q653L	TCGA-L4-A4E5	LUAD	TCGA	STSTGE	DEG_Kelch_Keap1_1	642:647	Mutation rewiring degron network	0.1667
p.Q653L	DO24320	LUAD	ICGC	STSTGE	DEG_Kelch_Keap1_1	642:647	Mutation rewiring degron network	0.1667
p.Q653L	DO23597	LUAD	ICGC	STSTGE	DEG_Kelch_Keap1_1	642:647	Mutation rewiring degron network	0.1667
p.Q353K	TCGA-44-7672	LUAD	TCGA	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1667
p.Q353K	DO23576	LUAD	ICGC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1667
p.C1194Y	TCGA-50-5933	LUAD	TCGA	VYSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.3056
p.C1194Y	DO24800	LUAD	ICGC	VYSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.3056
p.Q1140H	TCGA-55-6969	LUAD	TCGA	LRTPQLT	DEG_SCF_FBW7_1	1124:1130	Mutation rewiring degron network	0.0556
p.Q1140H	DO24586	LUAD	ICGC	LRTPQLT	DEG_SCF_FBW7_1	1124:1130	Mutation rewiring degron network	0.0556
p.W341R	TCGA-55-8089	LUAD	TCGA	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.2778
p.W341R	DO23690	LUAD	ICGC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.2778
p.H1139N	TCGA-55-8510	LUAD	TCGA	LRTPQLT	DEG_SCF_FBW7_1	1124:1130	Mutation rewiring degron network	0.0833
p.H1139N	DO24339	LUAD	ICGC	LRTPQLT	DEG_SCF_FBW7_1	1124:1130	Mutation rewiring degron network	0.0833
p.G348V	TCGA-97-7554	LUAD	TCGA	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.3056
p.G348V	DO23592	LUAD	ICGC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.3056
p.L98R	TCGA-AJ-A3EK	UCEC	TCGA	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1389
p.L98R	DO41584	UCEC	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1389
p.P107S	TCGA-AM-5821	COAD	TCGA	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation altering degron motif	0.6752
p.P107S	DO8240	COAD	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation altering degron motif	0.6752
p.R1120M	TCGA-BA-6869	HNSC	TCGA	LRTPQLT	DEG_SCF_FBW7_1	1124:1130	Mutation rewiring degron network	0.2222
p.R1120M	DO14250	HNSC	ICGC	LRTPQLT	DEG_SCF_FBW7_1	1124:1130	Mutation rewiring degron network	0.2222
p.M1206I	TCGA-BR-7723	STAD	TCGA	VYSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.1389
p.M1206I	DO38875	STAD	ICGC	VYSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.1389
p.K656T	TCGA-BR-8588	STAD	TCGA	STSTGE	DEG_Kelch_Keap1_1	642:647	Mutation substituting flanking lysine	0.1944
p.K656T	TCGA-VQ-AA68	STAD	TCGA	STSTGE	DEG_Kelch_Keap1_1	642:647	Mutation substituting flanking lysine	0.1944
p.K656T	DO234461	ESAD	ICGC	STSTGE	DEG_Kelch_Keap1_1	642:647	Mutation substituting flanking lysine	0.1944
p.K656T	DO51799	STAD	ICGC	STSTGE	DEG_Kelch_Keap1_1	642:647	Mutation substituting flanking lysine	0.1944
p.K656T	DO47855	STAD	ICGC	STSTGE	DEG_Kelch_Keap1_1	642:647	Mutation substituting flanking lysine	0.1944
p.T1207M	TCGA-CH-5769	PRAD	TCGA	VYSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.1111
p.T1207M	DO36245	PRAD	ICGC	VYSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.1111
p.W341C	TCGA-CN-A63U	HNSC	TCGA	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.2778
p.W341C	DO44454	HNSC	ICGC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.2778
p.G1123E	TCGA-EE-A181	SKCM	TCGA	LRTPQLT	DEG_SCF_FBW7_1	1124:1130	Mutation rewiring degron network	0.3056
p.G1123E	DO37444	SKCM	ICGC	LRTPQLT	DEG_SCF_FBW7_1	1124:1130	Mutation rewiring degron network	0.3056
p.T1126N	TCGA-EE-A2GU	SKCM	TCGA	LRTPQLT	DEG_SCF_FBW7_1	1124:1130	Mutation altering degron motif	0.7055
p.T1126N	DO37639	SKCM	ICGC	LRTPQLT	DEG_SCF_FBW7_1	1124:1130	Mutation altering degron motif	0.7055
p.M354L	TCGA-FI-A2D5	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1389
p.M354L	DO41331	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1389
p.E342K	TCGA-FW-A3R5	SKCM	TCGA	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.3056
p.E342K	DO37406	SKCM	ICGC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.3056
p.A336V	TCGA-IB-7651	PAAD	TCGA	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1389
p.A336V	DO46657	PAAD	ICGC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1389
p.E1136D	TCGA-L5-A88Y	ESCA	TCGA	LRTPQLT	DEG_SCF_FBW7_1	1124:1130	Mutation rewiring degron network	0.1667
p.F657V	TCGA-L5-A8NW	ESCA	TCGA	STSTGE	DEG_Kelch_Keap1_1	642:647	Mutation rewiring degron network	0.0556
p.P356T	TCGA-L9-A7SV	LUAD	TCGA	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.0833
p.P356T	DO49875	LUAD	ICGC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.0833
p.Q640L	TCGA-OR-A5KB	ACC	TCGA	STSTGE	DEG_Kelch_Keap1_1	642:647	Mutation rewiring degron network	0.2778
p.A336S	TCGA-XF-AAMG	BLCA	TCGA	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1389
p.A336S	DO219049	BLCA	ICGC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1389
p.E1115K	TCGA-ZF-A9R7	BLCA	TCGA	LRTPQLT	DEG_SCF_FBW7_1	1124:1130	Mutation rewiring degron network	0.0833
p.E1115K	DO219064	BLCA	ICGC	LRTPQLT	DEG_SCF_FBW7_1	1124:1130	Mutation rewiring degron network	0.0833
p.S637I	DO228856	LICA	ICGC	STSTGE	DEG_Kelch_Keap1_1	642:647	Mutation rewiring degron network	0.1944
p.D96H	DO229056	LICA	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0833
p.V338F	DO230993	LUSC	ICGC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM01020	Plasma Cell Myeloma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00584	Osteosarcoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00367	Small Cell Lung Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00362	Burkitt's Lymphoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00057	Neuroblastoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00002	Neuroblastoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00552	Rhabdomyosarcoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00457	Plasma Cell Myeloma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00260	Gastric Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00599	Osteosarcoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00360	Other Solid Cancers	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00365	Small Cell Lung Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00240	Cervical Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00616	Hepatocellular Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00613	Glioblastoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00986	Head and Neck Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00579	Neuroblastoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00233	T-Lymphoblastic Leukemia	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00503	Gastric Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00302	Other Solid Cancers	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM01498	Acute Myeloid Leukemia	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM01472	Hepatocellular Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00784	Glioma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM00248	Gastric Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM01559	Melanoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.V338F	SIDM01587	Bladder Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1944
p.T643M	DO224551	LUSC	ICGC	STSTGE	DEG_Kelch_Keap1_1	642:647	Mutation altering degron motif	0.6312
p.Q353E	DO227681	SKCA	ICGC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1667
p.K1190E	SIDM00625	Other Sarcomas	GDSC	VYSSS	DEG_SPOP_SBC_1	1195:1199	Mutation substituting flanking lysine	0.3056
p.K1190E	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	VYSSS	DEG_SPOP_SBC_1	1195:1199	Mutation substituting flanking lysine	0.3056
p.E1201K	SIDM01090	Colorectal Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.2778
p.K650N	SIDM01002	Breast Carcinoma	GDSC	STSTGE	DEG_Kelch_Keap1_1	642:647	Mutation substituting flanking lysine	0.3611
p.K1187Q	SIDM00193	Colorectal Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	1195:1199	Mutation substituting flanking lysine	0.2222
p.D96E	SIDM00482	Chronic Myelogenous Leukemia	GDSC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0833
p.Q1203R	SIDM01608	Endometrial Carcinoma	GDSC	VYSSS	DEG_SPOP_SBC_1	1195:1199	Mutation rewiring degron network	0.2222
p.F657L	ACH-000986	Colon/Colorectal Cancer	CCLE	STSTGE	DEG_Kelch_Keap1_1	642:647	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPATA31A6

UniProt ID: Q5VVP1

Entrez ID: 389730

Protein name: Spermatogenesis-associated protein 31A6 (Protein FAM75A6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPATA31A6 in