DegronMD

Uniprot ID: Q5VVP1

Source protein: Spermatogenesis-associated protein 31A6

Source gene: SPATA31A6

Class: DEG_SCF_FBW7_1

Location: 1124:1130

E3 ligase: FBXW7

DEGRON score: 0.9898

ASA_SCORE: 101.1714

COIL: 0.9311

CONS_SCORE: 0.358

DSS_SCORE: 0.6852

HELIX: 0.0277

FCONS_SCORE: 1.2942

RIG_SCORE: 0.6565

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1125G	TCGA-06-5416	GBM	TCGA	LRTPQLT	DEG_SCF_FBW7_1	0.6457
p.R1125G	DO10880	GBM	ICGC	LRTPQLT	DEG_SCF_FBW7_1	0.6457
p.Q1140H	TCGA-55-6969	LUAD	TCGA	LRTPQLT	DEG_SCF_FBW7_1	0.0556
p.Q1140H	DO24586	LUAD	ICGC	LRTPQLT	DEG_SCF_FBW7_1	0.0556
p.H1139N	TCGA-55-8510	LUAD	TCGA	LRTPQLT	DEG_SCF_FBW7_1	0.0833
p.H1139N	DO24339	LUAD	ICGC	LRTPQLT	DEG_SCF_FBW7_1	0.0833
p.R1120M	TCGA-BA-6869	HNSC	TCGA	LRTPQLT	DEG_SCF_FBW7_1	0.2222
p.R1120M	DO14250	HNSC	ICGC	LRTPQLT	DEG_SCF_FBW7_1	0.2222
p.G1123E	TCGA-EE-A181	SKCM	TCGA	LRTPQLT	DEG_SCF_FBW7_1	0.3056
p.G1123E	DO37444	SKCM	ICGC	LRTPQLT	DEG_SCF_FBW7_1	0.3056
p.T1126N	TCGA-EE-A2GU	SKCM	TCGA	LRTPQLT	DEG_SCF_FBW7_1	0.7055
p.T1126N	DO37639	SKCM	ICGC	LRTPQLT	DEG_SCF_FBW7_1	0.7055
p.E1136D	TCGA-L5-A88Y	ESCA	TCGA	LRTPQLT	DEG_SCF_FBW7_1	0.1667
p.E1115K	TCGA-ZF-A9R7	BLCA	TCGA	LRTPQLT	DEG_SCF_FBW7_1	0.0833
p.E1115K	DO219064	BLCA	ICGC	LRTPQLT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TZJ5	Spermatogenesis-associated protein 31A1	DEG_SCF_FBW7_1	1128:1134	LRTPQLT	FBXW7	0.9898	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	DEG_SCF_FBW7_1	1128:1134	LRTPQLT	FBXW7	0.7927	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_SCF_FBW7_1	1128:1134	LRTPQLT	FBXW7	0.7927	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_SCF_FBW7_1	1124:1130	LRTPQLT	FBXW7	0.9898	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	DEG_SCF_FBW7_1	1128:1134	LRTPQLT	FBXW7	0.749	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons