DegronMD

Uniprot ID: Q5VYP0

Source protein: Spermatogenesis-associated protein 31A3

Source gene: SPATA31A3

Class: DEG_SCF_FBW7_1

Location: 1128:1134

E3 ligase: FBXW7

DEGRON score: 0.749

ASA_SCORE: 96.8143

COIL: 0.931

CONS_SCORE: 0.3473

DSS_SCORE: 0.6648

HELIX: 0.0304

FCONS_SCORE: 1.0218

RIG_SCORE: 0.6675

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1125I	TCGA-05-4410	LUAD	TCGA	LRTPQLT	DEG_SCF_FBW7_1	0.25
p.L1125I	DO25426	LUAD	ICGC	LRTPQLT	DEG_SCF_FBW7_1	0.25
p.R1124M	TCGA-AP-A059	UCEC	TCGA	LRTPQLT	DEG_SCF_FBW7_1	0.2222
p.R1124M	DO41361	UCEC	ICGC	LRTPQLT	DEG_SCF_FBW7_1	0.2222
p.V1136G	TCGA-F5-6814	READ	TCGA	LRTPQLT	DEG_SCF_FBW7_1	0.2778
p.V1136G	DO36556	READ	ICGC	LRTPQLT	DEG_SCF_FBW7_1	0.2778
p.L1125H	TCGA-L5-A4ON	ESCA	TCGA	LRTPQLT	DEG_SCF_FBW7_1	0.25
p.L1125H	DO231204	LUSC	ICGC	LRTPQLT	DEG_SCF_FBW7_1	0.25
p.P1135T	DO228948	LICA	ICGC	LRTPQLT	DEG_SCF_FBW7_1	0.3056
p.Q1144K	DO229032	LICA	ICGC	LRTPQLT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TZJ5	Spermatogenesis-associated protein 31A1	DEG_SCF_FBW7_1	1128:1134	LRTPQLT	FBXW7	0.9898	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	DEG_SCF_FBW7_1	1128:1134	LRTPQLT	FBXW7	0.7927	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_SCF_FBW7_1	1128:1134	LRTPQLT	FBXW7	0.7927	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_SCF_FBW7_1	1124:1130	LRTPQLT	FBXW7	0.9898	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	DEG_SCF_FBW7_1	1128:1134	LRTPQLT	FBXW7	0.749	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons