DegronMD - Q5VYP0(SPATA31A3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1125I	TCGA-05-4410	LUAD	TCGA	LRTPQLT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.25
p.L1125I	DO25426	LUAD	ICGC	LRTPQLT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.25
p.G106E	TCGA-2W-A8YY	CESC	TCGA	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation altering degron motif	0.6087
p.G106E	DO223732	CESC	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation altering degron motif	0.6087
p.T1211M	TCGA-AA-3811	COAD	TCGA	VYSSS	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.1111
p.T1211M	TCGA-B5-A3FC	UCEC	TCGA	VYSSS	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.1111
p.T1211M	DO7962	COAD	ICGC	VYSSS	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.1111
p.T1211M	DO227977	COCA	ICGC	VYSSS	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.1111
p.T1211M	DO41871	UCEC	ICGC	VYSSS	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.1111
p.R1124M	TCGA-AP-A059	UCEC	TCGA	LRTPQLT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.2222
p.R1124M	DO41361	UCEC	ICGC	LRTPQLT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.2222
p.Q116K	TCGA-AP-A1DP	UCEC	TCGA	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1667
p.Q116K	DO42336	UCEC	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1667
p.T1211A	TCGA-B5-A3FC	UCEC	TCGA	VYSSS	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.1111
p.T1211A	DO41871	UCEC	ICGC	VYSSS	DEG_SPOP_SBC_1	1199:1203	Mutation rewiring degron network	0.1111
p.P120T	TCGA-CR-7398	HNSC	TCGA	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.P120T	DO14782	HNSC	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.S1203I	TCGA-DD-AADB	LIHC	TCGA	VYSSS	DEG_SPOP_SBC_1	1199:1203	Mutation altering degron motif	0.7341
p.S1203I	DO52229	LIHC	ICGC	VYSSS	DEG_SPOP_SBC_1	1199:1203	Mutation altering degron motif	0.7341
p.G119S	TCGA-EE-A180	SKCM	TCGA	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0833
p.G119S	DO47537	SKCM	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0833
p.S652I	TCGA-EO-A3AY	UCEC	TCGA	SMSTGE	DEG_Kelch_Keap1_1	646:651	Mutation rewiring degron network	0.3056
p.S652I	DO43202	UCEC	ICGC	SMSTGE	DEG_Kelch_Keap1_1	646:651	Mutation rewiring degron network	0.3056
p.L105M	TCGA-EO-A3B0	UCEC	TCGA	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation altering degron motif	0.5999
p.L105M	DO219773	UCEC	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation altering degron motif	0.5999
p.V1136G	TCGA-F5-6814	READ	TCGA	LRTPQLT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.2778
p.V1136G	DO36556	READ	ICGC	LRTPQLT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.2778
p.L1125H	TCGA-L5-A4ON	ESCA	TCGA	LRTPQLT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.25
p.L1125H	DO231204	LUSC	ICGC	LRTPQLT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.25
p.P1135T	DO228948	LICA	ICGC	LRTPQLT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.3056
p.W643L	DO228976	LICA	ICGC	SMSTGE	DEG_Kelch_Keap1_1	646:651	Mutation rewiring degron network	0.25
p.Q1144K	DO229032	LICA	ICGC	LRTPQLT	DEG_SCF_FBW7_1	1128:1134	Mutation rewiring degron network	0.0556
p.T335R	DO229061	LICA	ICGC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1111
p.L109P	DO229232	THCA	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation altering degron motif	0.6471
p.V659A	SIDM01314	Colorectal Carcinoma	GDSC	SMSTGE	DEG_Kelch_Keap1_1	646:651	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPATA31A3

UniProt ID: Q5VYP0

Entrez ID: 727830

Protein name: Spermatogenesis-associated protein 31A3 (Protein FAM75A3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPATA31A3 in