DegronMD

Uniprot ID: Q5VYP0

Source protein: Spermatogenesis-associated protein 31A3

Source gene: SPATA31A3

Class: LIG_APCC_ABBA_1

Location: 105:110

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9544

ASA_SCORE: 69.35

COIL: 0.8088

CONS_SCORE: 0.4114

DSS_SCORE: 0.5562

HELIX: 0.133

FCONS_SCORE: 1.0152

RIG_SCORE: 0.6709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G106E	TCGA-2W-A8YY	CESC	TCGA	LGPHLD	LIG_APCC_ABBA_1	0.6087
p.G106E	DO223732	CESC	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.6087
p.Q116K	TCGA-AP-A1DP	UCEC	TCGA	LGPHLD	LIG_APCC_ABBA_1	0.1667
p.Q116K	DO42336	UCEC	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.1667
p.P120T	TCGA-CR-7398	HNSC	TCGA	LGPHLD	LIG_APCC_ABBA_1	0.0556
p.P120T	DO14782	HNSC	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.0556
p.G119S	TCGA-EE-A180	SKCM	TCGA	LGPHLD	LIG_APCC_ABBA_1	0.0833
p.G119S	DO47537	SKCM	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.0833
p.L105M	TCGA-EO-A3B0	UCEC	TCGA	LGPHLD	LIG_APCC_ABBA_1	0.5999
p.L105M	DO219773	UCEC	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.5999
p.L109P	DO229232	THCA	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TZJ5	Spermatogenesis-associated protein 31A1	LIG_APCC_ABBA_1	105:110	LGPHLD	APC,CDC20,FZR1	0.9874	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	LIG_APCC_ABBA_1	105:110	LGPHLD	APC,CDC20,FZR1	0.8604	More...
Q5VU36	Spermatogenesis-associated protein 31A5	LIG_APCC_ABBA_1	105:110	LGPHLD	APC,CDC20,FZR1	0.8887	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	LIG_APCC_ABBA_1	105:110	LGPHLD	APC,CDC20,FZR1	0.994	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	LIG_APCC_ABBA_1	105:110	LGPHLD	APC,CDC20,FZR1	0.9544	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons