DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LGPHLD
Uniprot ID:
Q5TZJ5
Source protein:
Spermatogenesis-associated protein 31A1
Source gene:
SPATA31A1
Class:
LIG_APCC_ABBA_1
Location:
105:110
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9874
ASA_SCORE:
74.8833
COIL:
0.8577
CONS_SCORE:
0.4054
DSS_SCORE:
0.5662
HELIX:
0.0772
FCONS_SCORE:
1.1749
RIG_SCORE:
0.6702
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P102Q
SIDM00855
Other Sarcomas
GDSC
LGPHLD
LIG_APCC_ABBA_1
0.25
p.Q106E
SIDM01592
Breast Carcinoma
GDSC
LGPHLD
LIG_APCC_ABBA_1
0.6744
Drug responses associated with SPATA31A1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LGPHLD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5TZJ5
Spermatogenesis-associated protein 31A1
LIG_APCC_ABBA_1
105:110
LGPHLD
APC,CDC20,FZR1
0.9874
More...
Q8IWB4
Spermatogenesis-associated protein 31A7
LIG_APCC_ABBA_1
105:110
LGPHLD
APC,CDC20,FZR1
0.8604
More...
Q5VU36
Spermatogenesis-associated protein 31A5
LIG_APCC_ABBA_1
105:110
LGPHLD
APC,CDC20,FZR1
0.8887
More...
Q5VVP1
Spermatogenesis-associated protein 31A6
LIG_APCC_ABBA_1
105:110
LGPHLD
APC,CDC20,FZR1
0.994
More...
Q5VYP0
Spermatogenesis-associated protein 31A3
LIG_APCC_ABBA_1
105:110
LGPHLD
APC,CDC20,FZR1
0.9544
More...