DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LGPHLD
Uniprot ID:
Q5VU36
Source protein:
Spermatogenesis-associated protein 31A5
Source gene:
SPATA31A5
Class:
LIG_APCC_ABBA_1
Location:
105:110
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8887
ASA_SCORE:
75.55
COIL:
0.8292
CONS_SCORE:
0.4115
DSS_SCORE:
0.5562
HELIX:
0.111
FCONS_SCORE:
1.0152
RIG_SCORE:
0.6709
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L109P
DO48414
BLCA
ICGC
LGPHLD
LIG_APCC_ABBA_1
0.6471
p.L109P
DO229248
THCA
ICGC
LGPHLD
LIG_APCC_ABBA_1
0.6471
Drug responses associated with SPATA31A5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LGPHLD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5TZJ5
Spermatogenesis-associated protein 31A1
LIG_APCC_ABBA_1
105:110
LGPHLD
APC,CDC20,FZR1
0.9874
More...
Q8IWB4
Spermatogenesis-associated protein 31A7
LIG_APCC_ABBA_1
105:110
LGPHLD
APC,CDC20,FZR1
0.8604
More...
Q5VU36
Spermatogenesis-associated protein 31A5
LIG_APCC_ABBA_1
105:110
LGPHLD
APC,CDC20,FZR1
0.8887
More...
Q5VVP1
Spermatogenesis-associated protein 31A6
LIG_APCC_ABBA_1
105:110
LGPHLD
APC,CDC20,FZR1
0.994
More...
Q5VYP0
Spermatogenesis-associated protein 31A3
LIG_APCC_ABBA_1
105:110
LGPHLD
APC,CDC20,FZR1
0.9544
More...