DegronMD

Uniprot ID: Q8IWB4

Source protein: Spermatogenesis-associated protein 31A7

Source gene: SPATA31A7

Class: LIG_APCC_ABBA_1

Location: 105:110

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8604

ASA_SCORE: 73.55

COIL: 0.8195

CONS_SCORE: 0.4115

DSS_SCORE: 0.5696

HELIX: 0.1025

FCONS_SCORE: 1.0152

RIG_SCORE: 0.6705

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S95L	TCGA-12-1597	GBM	TCGA	LGPHLD	LIG_APCC_ABBA_1	0.0556
p.S95L	TCGA-B5-A0JY	UCEC	TCGA	LGPHLD	LIG_APCC_ABBA_1	0.0556
p.S95L	DO12424	GBM	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.0556
p.S95L	DO43041	UCEC	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.0556
p.L98R	TCGA-AJ-A3EK	UCEC	TCGA	LGPHLD	LIG_APCC_ABBA_1	0.1389
p.L98R	DO41584	UCEC	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.1389
p.S95W	TCGA-DS-A1OA	CESC	TCGA	LGPHLD	LIG_APCC_ABBA_1	0.0556
p.S95W	DO6341	CESC	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.0556
p.S95W	DO229353	LAML	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.0556
p.L101P	DO1088	BRCA	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.2222
p.G119D	SIDM01191	Osteosarcoma	GDSC	LGPHLD	LIG_APCC_ABBA_1	0.0833
p.G115D	SIDM01752	Pancreatic Carcinoma	GDSC	LGPHLD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TZJ5	Spermatogenesis-associated protein 31A1	LIG_APCC_ABBA_1	105:110	LGPHLD	APC,CDC20,FZR1	0.9874	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	LIG_APCC_ABBA_1	105:110	LGPHLD	APC,CDC20,FZR1	0.8604	More...
Q5VU36	Spermatogenesis-associated protein 31A5	LIG_APCC_ABBA_1	105:110	LGPHLD	APC,CDC20,FZR1	0.8887	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	LIG_APCC_ABBA_1	105:110	LGPHLD	APC,CDC20,FZR1	0.994	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	LIG_APCC_ABBA_1	105:110	LGPHLD	APC,CDC20,FZR1	0.9544	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons