DegronMD - Q8IWB4(SPATA31A7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S95L	TCGA-12-1597	GBM	TCGA	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.S95L	TCGA-B5-A0JY	UCEC	TCGA	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.S95L	DO12424	GBM	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.S95L	DO43041	UCEC	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.W341S	TCGA-17-Z007	LUAD	TCGA	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.2778
p.R353L	TCGA-60-2704	LUSC	TCGA	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1667
p.R353L	DO26555	LUSC	ICGC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1667
p.L98R	TCGA-AJ-A3EK	UCEC	TCGA	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1389
p.L98R	DO41584	UCEC	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1389
p.S95W	TCGA-DS-A1OA	CESC	TCGA	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.S95W	DO6341	CESC	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.S95W	DO229353	LAML	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.T351K	TCGA-E9-A5FK	BRCA	TCGA	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.2222
p.T351K	DO44192	BRCA	ICGC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.2222
p.L101P	DO1088	BRCA	ICGC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.2222
p.S170P	DO229234	THCA	ICGC	PMTTS	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.25
p.A262T	DO229245	THCA	ICGC	LSPHED	LIG_APCC_ABBA_1	254:259	Mutation rewiring degron network	0.25
p.G119D	SIDM01191	Osteosarcoma	GDSC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0833
p.G115D	SIDM01752	Pancreatic Carcinoma	GDSC	LGPHLD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1944
p.T355N	SIDM01387	Small Cell Lung Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1111
p.T355N	ACH-000921	Lung Cancer	CCLE	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.1111
p.T351A	ACH-000819	Brain Cancer	CCLE	EKENV	DEG_APCC_KENBOX_2	343:347	Mutation rewiring degron network	0.2222

Kaplan plot for SPATA31A7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPATA31A7

UniProt ID: Q8IWB4

Entrez ID: 26165

Protein name: Spermatogenesis-associated protein 31A7 (Protein FAM75A7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPATA31A7 in