DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LSPHED
Uniprot ID:
Q8IWB4
Source protein:
Spermatogenesis-associated protein 31A7
Source gene:
SPATA31A7
Class:
LIG_APCC_ABBA_1
Location:
254:259
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7107
ASA_SCORE:
81.65
COIL:
0.721
CONS_SCORE:
0.3811
DSS_SCORE:
0.4168
HELIX:
0.2332
FCONS_SCORE:
0.8751
RIG_SCORE:
0.7259
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A262T
DO229245
THCA
ICGC
LSPHED
LIG_APCC_ABBA_1
0.25
Drug responses associated with SPATA31A7 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LSPHED
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IWB4
Spermatogenesis-associated protein 31A7
LIG_APCC_ABBA_1
254:259
LSPHED
APC,CDC20,FZR1
0.7107
More...