DegronMD

Uniprot ID: Q8IWB4

Source protein: Spermatogenesis-associated protein 31A7

Source gene: SPATA31A7

Class: DEG_APCC_KENBOX_2

Location: 343:347

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9054

ASA_SCORE: 109.78

COIL: 0.5818

CONS_SCORE: 0.6113

DSS_SCORE: 0.3532

HELIX: 0.255

FCONS_SCORE: 1.6247

RIG_SCORE: 0.8146

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W341S	TCGA-17-Z007	LUAD	TCGA	EKENV	DEG_APCC_KENBOX_2	0.2778
p.R353L	TCGA-60-2704	LUSC	TCGA	EKENV	DEG_APCC_KENBOX_2	0.1667
p.R353L	DO26555	LUSC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.1667
p.T351K	TCGA-E9-A5FK	BRCA	TCGA	EKENV	DEG_APCC_KENBOX_2	0.2222
p.T351K	DO44192	BRCA	ICGC	EKENV	DEG_APCC_KENBOX_2	0.2222
p.T355N	SIDM01387	Small Cell Lung Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1111
p.T355N	ACH-000921	Lung Cancer	CCLE	EKENV	DEG_APCC_KENBOX_2	0.1111
p.T351A	ACH-000819	Brain Cancer	CCLE	EKENV	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75152	Zinc finger CCCH domain-containing protein 11A	DEG_APCC_KENBOX_2	253:257	EKENV	APC,CDC20,FZR1	0.9975	More...
P52179	Myomesin-1	DEG_APCC_KENBOX_2	290:294	EKENV	APC,CDC20,FZR1	0.6123	More...
Q5VWN6	Protein TASOR 2	DEG_APCC_KENBOX_2	1450:1454	EKENV	APC,CDC20,FZR1	0.753	More...
Q86XI2	Condensin-2 complex subunit G2	DEG_APCC_KENBOX_2	600:604	EKENV	APC,CDC20,FZR1	0.6924	More...
Q8TDB4	Protein MGARP	DEG_APCC_KENBOX_2	95:99	EKENV	APC,CDC20,FZR1	0.8967	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_APCC_KENBOX_2	1130:1134	EKENV	APC,CDC20,FZR1	0.8157	More...
Q5TZJ5	Spermatogenesis-associated protein 31A1	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9969	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9054	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9543	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9667	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9511	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons