DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
EKENV
Uniprot ID:
Q9C0D2
Source protein:
Centrosomal protein of 295 kDa
Source gene:
CEP295
Class:
DEG_APCC_KENBOX_2
Location:
1130:1134
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8157
ASA_SCORE:
125.06
COIL:
0.8338
CONS_SCORE:
0.3156
DSS_SCORE:
0.2874
HELIX:
0.145
FCONS_SCORE:
0.9415
RIG_SCORE:
0.7008
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P1120R
SIDM01145
Gastric Carcinoma
GDSC
EKENV
DEG_APCC_KENBOX_2
0.0556
p.P1120R
NCI-SNU-16
stomach
COSMIC
EKENV
DEG_APCC_KENBOX_2
0.0556
Drug responses associated with CEP295 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of EKENV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75152
Zinc finger CCCH domain-containing protein 11A
DEG_APCC_KENBOX_2
253:257
EKENV
APC,CDC20,FZR1
0.9975
More...
P52179
Myomesin-1
DEG_APCC_KENBOX_2
290:294
EKENV
APC,CDC20,FZR1
0.6123
More...
Q5VWN6
Protein TASOR 2
DEG_APCC_KENBOX_2
1450:1454
EKENV
APC,CDC20,FZR1
0.753
More...
Q86XI2
Condensin-2 complex subunit G2
DEG_APCC_KENBOX_2
600:604
EKENV
APC,CDC20,FZR1
0.6924
More...
Q8TDB4
Protein MGARP
DEG_APCC_KENBOX_2
95:99
EKENV
APC,CDC20,FZR1
0.8967
More...
Q9C0D2
Centrosomal protein of 295 kDa
DEG_APCC_KENBOX_2
1130:1134
EKENV
APC,CDC20,FZR1
0.8157
More...
Q5TZJ5
Spermatogenesis-associated protein 31A1
DEG_APCC_KENBOX_2
343:347
EKENV
APC,CDC20,FZR1
0.9969
More...
Q8IWB4
Spermatogenesis-associated protein 31A7
DEG_APCC_KENBOX_2
343:347
EKENV
APC,CDC20,FZR1
0.9054
More...
Q5VU36
Spermatogenesis-associated protein 31A5
DEG_APCC_KENBOX_2
343:347
EKENV
APC,CDC20,FZR1
0.9543
More...
Q5VVP1
Spermatogenesis-associated protein 31A6
DEG_APCC_KENBOX_2
343:347
EKENV
APC,CDC20,FZR1
0.9667
More...
Q5VYP0
Spermatogenesis-associated protein 31A3
DEG_APCC_KENBOX_2
343:347
EKENV
APC,CDC20,FZR1
0.9511
More...