DegronMD

Uniprot ID: Q5TZJ5

Source protein: Spermatogenesis-associated protein 31A1

Source gene: SPATA31A1

Class: DEG_APCC_KENBOX_2

Location: 343:347

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9969

ASA_SCORE: 114.08

COIL: 0.6226

CONS_SCORE: 0.4734

DSS_SCORE: 0.4011

HELIX: 0.2866

FCONS_SCORE: 1.6135

RIG_SCORE: 0.7942

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E357K	DO52345	LUSC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.0556
p.V342L	SIDM00845	Burkitt's Lymphoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.3056
p.G338V	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.Q339H	SIDM00924	Other Solid Cancers	GDSC	EKENV	DEG_APCC_KENBOX_2	0.2222
p.V342M	SIDM00220	Ovarian Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.3056
p.A350T	SIDM01750	Melanoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75152	Zinc finger CCCH domain-containing protein 11A	DEG_APCC_KENBOX_2	253:257	EKENV	APC,CDC20,FZR1	0.9975	More...
P52179	Myomesin-1	DEG_APCC_KENBOX_2	290:294	EKENV	APC,CDC20,FZR1	0.6123	More...
Q5VWN6	Protein TASOR 2	DEG_APCC_KENBOX_2	1450:1454	EKENV	APC,CDC20,FZR1	0.753	More...
Q86XI2	Condensin-2 complex subunit G2	DEG_APCC_KENBOX_2	600:604	EKENV	APC,CDC20,FZR1	0.6924	More...
Q8TDB4	Protein MGARP	DEG_APCC_KENBOX_2	95:99	EKENV	APC,CDC20,FZR1	0.8967	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_APCC_KENBOX_2	1130:1134	EKENV	APC,CDC20,FZR1	0.8157	More...
Q5TZJ5	Spermatogenesis-associated protein 31A1	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9969	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9054	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9543	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9667	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9511	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons