DegronMD

Uniprot ID: Q86XI2

Source protein: Condensin-2 complex subunit G2

Source gene: NCAPG2

Class: DEG_APCC_KENBOX_2

Location: 600:604

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6924

ASA_SCORE: 110.34

COIL: 0.5712

CONS_SCORE: 0.3972

DSS_SCORE: 0.4754

HELIX: 0.3764

FCONS_SCORE: 1.4212

RIG_SCORE: 0.7396

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S612L	TCGA-60-2720	LUSC	TCGA	EKENV	DEG_APCC_KENBOX_2	0.1111
p.S612L	DO26587	LUSC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.1111
p.T610I	TCGA-DU-6392	LGG	TCGA	EKENV	DEG_APCC_KENBOX_2	0.1667
p.T610I	DO22237	LGG	ICGC	EKENV	DEG_APCC_KENBOX_2	0.1667
p.P590L	TCGA-FS-A1Z3	SKCM	TCGA	EKENV	DEG_APCC_KENBOX_2	0.0556
p.P590L	DO37635	SKCM	ICGC	EKENV	DEG_APCC_KENBOX_2	0.0556
p.E600Q	SIDM01265	Plasma Cell Myeloma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.5633
p.E600Q	SIDM00442	Thyroid Gland Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.5633
p.E600Q	SIDM00309	Mesothelioma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.5633
p.N614D	SIDM00633	Breast Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.0556
p.N614D	SIDM00849	Kidney Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.0556
p.N614D	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.0556
p.N614D	SIDM00954	Breast Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.0556
p.G598R	SIDM00171	Colorectal Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.2778
p.G598R	ACH-000412	Colon/Colorectal Cancer	CCLE	EKENV	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75152	Zinc finger CCCH domain-containing protein 11A	DEG_APCC_KENBOX_2	253:257	EKENV	APC,CDC20,FZR1	0.9975	More...
P52179	Myomesin-1	DEG_APCC_KENBOX_2	290:294	EKENV	APC,CDC20,FZR1	0.6123	More...
Q5VWN6	Protein TASOR 2	DEG_APCC_KENBOX_2	1450:1454	EKENV	APC,CDC20,FZR1	0.753	More...
Q86XI2	Condensin-2 complex subunit G2	DEG_APCC_KENBOX_2	600:604	EKENV	APC,CDC20,FZR1	0.6924	More...
Q8TDB4	Protein MGARP	DEG_APCC_KENBOX_2	95:99	EKENV	APC,CDC20,FZR1	0.8967	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_APCC_KENBOX_2	1130:1134	EKENV	APC,CDC20,FZR1	0.8157	More...
Q5TZJ5	Spermatogenesis-associated protein 31A1	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9969	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9054	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9543	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9667	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9511	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons