DegronMD - Q8TDB4(MGARP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E174K	TCGA-18-3409	LUSC	TCGA	PETTPEVT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.591
p.E174K	DO48362	BLCA	ICGC	PETTPEVT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.591
p.E174K	DO26444	LUSC	ICGC	PETTPEVT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.591
p.N181H	TCGA-AA-3510	COAD	TCGA	PETTPEVT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.3056
p.N181H	DO7783	COAD	ICGC	PETTPEVT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.3056
p.A100V	TCGA-AN-A046	BRCA	TCGA	EKENV	DEG_APCC_KENBOX_2	95:99	Mutation rewiring degron network	0.3056
p.A100V	DO1285	BRCA	ICGC	EKENV	DEG_APCC_KENBOX_2	95:99	Mutation rewiring degron network	0.3056
p.I89M	TCGA-EO-A22U	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	95:99	Mutation rewiring degron network	0.1667
p.I89M	DO43755	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	95:99	Mutation rewiring degron network	0.1667
p.E186Q	TCGA-ZF-AA51	BLCA	TCGA	PETTPEVT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.1667
p.E186Q	DO219093	BLCA	ICGC	PETTPEVT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.1667
p.E170V	DO233852	GACA	ICGC	PETTPEVT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.25
p.A183D	DO229041	LICA	ICGC	PETTPEVT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.25
p.E178K	SIDM01058	B-Cell Non-Hodgkin's Lymphoma	GDSC	PETTPEVT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.591
p.E178K	ACH-000073	Lymphoma	CCLE	PETTPEVT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.591
p.E178K	GRANTA-519	haematopoietic and lymphoid tissue	COSMIC	PETTPEVT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.591
p.P177S	SIDM01015	Chronic Myelogenous Leukemia	GDSC	PETTPEVT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.6752
p.P177S	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	PETTPEVT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.6752
p.S106N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	EKENV	DEG_APCC_KENBOX_2	95:99	Mutation rewiring degron network	0.1389
p.S106N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	EKENV	DEG_APCC_KENBOX_2	95:99	Mutation rewiring degron network	0.1389
p.S106N	ACH-000995	Leukemia	CCLE	EKENV	DEG_APCC_KENBOX_2	95:99	Mutation rewiring degron network	0.1389
p.S106N	Jurkat	haematopoietic and lymphoid tissue	COSMIC	EKENV	DEG_APCC_KENBOX_2	95:99	Mutation rewiring degron network	0.1389
p.A100E	SIDM01316	Ewing's Sarcoma	GDSC	EKENV	DEG_APCC_KENBOX_2	95:99	Mutation rewiring degron network	0.3056
p.A100E	ACH-000041	Bone Cancer	CCLE	EKENV	DEG_APCC_KENBOX_2	95:99	Mutation rewiring degron network	0.3056

Kaplan plot for MGARP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MGARP

UniProt ID: Q8TDB4

Entrez ID: 84709

Protein name: Protein MGARP (Corneal endothelium-specific protein 1) (CESP-1) (Hypoxia up-regulated mitochondrial movement regulator protein) (Mitochondria-localized glutamic acid-rich protein) (Ovary-specific acidic protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MGARP in