DegronMD

Uniprot ID: Q8TDB4

Source protein: Protein MGARP

Source gene: MGARP

Class: DEG_APCC_KENBOX_2

Location: 95:99

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8967

ASA_SCORE: 103.24

COIL: 0.6128

CONS_SCORE: 0.6886

DSS_SCORE: 0.6411

HELIX: 0.3624

FCONS_SCORE: 1.0055

RIG_SCORE: 0.6827

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A100V	TCGA-AN-A046	BRCA	TCGA	EKENV	DEG_APCC_KENBOX_2	0.3056
p.A100V	DO1285	BRCA	ICGC	EKENV	DEG_APCC_KENBOX_2	0.3056
p.I89M	TCGA-EO-A22U	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	0.1667
p.I89M	DO43755	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.1667
p.S106N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1389
p.S106N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1389
p.S106N	ACH-000995	Leukemia	CCLE	EKENV	DEG_APCC_KENBOX_2	0.1389
p.S106N	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	EKENV	DEG_APCC_KENBOX_2	0.1389
p.A100E	SIDM01316	Ewing's Sarcoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.3056
p.A100E	ACH-000041	Bone Cancer	CCLE	EKENV	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75152	Zinc finger CCCH domain-containing protein 11A	DEG_APCC_KENBOX_2	253:257	EKENV	APC,CDC20,FZR1	0.9975	More...
P52179	Myomesin-1	DEG_APCC_KENBOX_2	290:294	EKENV	APC,CDC20,FZR1	0.6123	More...
Q5VWN6	Protein TASOR 2	DEG_APCC_KENBOX_2	1450:1454	EKENV	APC,CDC20,FZR1	0.753	More...
Q86XI2	Condensin-2 complex subunit G2	DEG_APCC_KENBOX_2	600:604	EKENV	APC,CDC20,FZR1	0.6924	More...
Q8TDB4	Protein MGARP	DEG_APCC_KENBOX_2	95:99	EKENV	APC,CDC20,FZR1	0.8967	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_APCC_KENBOX_2	1130:1134	EKENV	APC,CDC20,FZR1	0.8157	More...
Q5TZJ5	Spermatogenesis-associated protein 31A1	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9969	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9054	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9543	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9667	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9511	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons