DegronMD

Uniprot ID: Q5VVP1

Source protein: Spermatogenesis-associated protein 31A6

Source gene: SPATA31A6

Class: DEG_APCC_KENBOX_2

Location: 343:347

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9667

ASA_SCORE: 105.12

COIL: 0.5164

CONS_SCORE: 0.4729

DSS_SCORE: 0.4089

HELIX: 0.4194

FCONS_SCORE: 1.5714

RIG_SCORE: 0.8092

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q353K	TCGA-44-7672	LUAD	TCGA	EKENV	DEG_APCC_KENBOX_2	0.1667
p.Q353K	DO23576	LUAD	ICGC	EKENV	DEG_APCC_KENBOX_2	0.1667
p.W341R	TCGA-55-8089	LUAD	TCGA	EKENV	DEG_APCC_KENBOX_2	0.2778
p.W341R	DO23690	LUAD	ICGC	EKENV	DEG_APCC_KENBOX_2	0.2778
p.G348V	TCGA-97-7554	LUAD	TCGA	EKENV	DEG_APCC_KENBOX_2	0.3056
p.G348V	DO23592	LUAD	ICGC	EKENV	DEG_APCC_KENBOX_2	0.3056
p.W341C	TCGA-CN-A63U	HNSC	TCGA	EKENV	DEG_APCC_KENBOX_2	0.2778
p.W341C	DO44454	HNSC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.2778
p.M354L	TCGA-FI-A2D5	UCEC	TCGA	EKENV	DEG_APCC_KENBOX_2	0.1389
p.M354L	DO41331	UCEC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.1389
p.E342K	TCGA-FW-A3R5	SKCM	TCGA	EKENV	DEG_APCC_KENBOX_2	0.3056
p.E342K	DO37406	SKCM	ICGC	EKENV	DEG_APCC_KENBOX_2	0.3056
p.A336V	TCGA-IB-7651	PAAD	TCGA	EKENV	DEG_APCC_KENBOX_2	0.1389
p.A336V	DO46657	PAAD	ICGC	EKENV	DEG_APCC_KENBOX_2	0.1389
p.P356T	TCGA-L9-A7SV	LUAD	TCGA	EKENV	DEG_APCC_KENBOX_2	0.0833
p.P356T	DO49875	LUAD	ICGC	EKENV	DEG_APCC_KENBOX_2	0.0833
p.A336S	TCGA-XF-AAMG	BLCA	TCGA	EKENV	DEG_APCC_KENBOX_2	0.1389
p.A336S	DO219049	BLCA	ICGC	EKENV	DEG_APCC_KENBOX_2	0.1389
p.V338F	DO230993	LUSC	ICGC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM01020	Plasma Cell Myeloma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00584	Osteosarcoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00367	Small Cell Lung Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00362	Burkitt's Lymphoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00057	Neuroblastoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00002	Neuroblastoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00552	Rhabdomyosarcoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00457	Plasma Cell Myeloma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00260	Gastric Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00599	Osteosarcoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00360	Other Solid Cancers	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00365	Small Cell Lung Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00240	Cervical Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00616	Hepatocellular Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00613	Glioblastoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00986	Head and Neck Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00579	Neuroblastoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00233	T-Lymphoblastic Leukemia	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00503	Gastric Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00302	Other Solid Cancers	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM01498	Acute Myeloid Leukemia	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM01472	Hepatocellular Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00784	Glioma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM00248	Gastric Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM01559	Melanoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.V338F	SIDM01587	Bladder Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	0.1944
p.Q353E	DO227681	SKCA	ICGC	EKENV	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75152	Zinc finger CCCH domain-containing protein 11A	DEG_APCC_KENBOX_2	253:257	EKENV	APC,CDC20,FZR1	0.9975	More...
P52179	Myomesin-1	DEG_APCC_KENBOX_2	290:294	EKENV	APC,CDC20,FZR1	0.6123	More...
Q5VWN6	Protein TASOR 2	DEG_APCC_KENBOX_2	1450:1454	EKENV	APC,CDC20,FZR1	0.753	More...
Q86XI2	Condensin-2 complex subunit G2	DEG_APCC_KENBOX_2	600:604	EKENV	APC,CDC20,FZR1	0.6924	More...
Q8TDB4	Protein MGARP	DEG_APCC_KENBOX_2	95:99	EKENV	APC,CDC20,FZR1	0.8967	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_APCC_KENBOX_2	1130:1134	EKENV	APC,CDC20,FZR1	0.8157	More...
Q5TZJ5	Spermatogenesis-associated protein 31A1	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9969	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9054	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9543	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9667	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	DEG_APCC_KENBOX_2	343:347	EKENV	APC,CDC20,FZR1	0.9511	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EKENV

Degron related mutations and impact score

Drug responses associated with SPATA31A6 mutations

All proteins holding degron of EKENV