DegronMD - Q5VWN6(TASOR2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1099L	SIDM01951	Colorectal Carcinoma	GDSC	PVSTS	DEG_SPOP_SBC_1	1095:1099	Mutation altering degron motif	0.7667
p.S1099L	SIDM00705	Non-Cancerous	GDSC	PVSTS	DEG_SPOP_SBC_1	1095:1099	Mutation altering degron motif	0.7667
p.S1099L	SIDM00706	Small Cell Lung Carcinoma	GDSC	PVSTS	DEG_SPOP_SBC_1	1095:1099	Mutation altering degron motif	0.7667
p.L557I	SIDM00994	T-Lymphoblastic Leukemia	GDSC	ATSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1111
p.L557I	SIDM00985	Burkitt's Lymphoma	GDSC	ATSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1111
p.L557I	SIDM00935	Other Solid Cancers	GDSC	ATSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1111
p.L557I	SIDM00399	Head and Neck Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1111
p.L557I	SIDM00731	Small Cell Lung Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1111
p.L557I	SIDM01087	Melanoma	GDSC	ATSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1111
p.L557I	SIDM00820	Kidney Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1111
p.L557I	SIDM00878	Breast Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1111
p.L557I	SIDM01100	Neuroblastoma	GDSC	ATSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1111
p.L557I	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	ATSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1111
p.L557I	SIDM00130	Pancreatic Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1111
p.L557I	SIDM00516	Melanoma	GDSC	ATSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1111
p.L557I	SIDM01879	Non-Cancerous	GDSC	ATSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1111
p.L557I	SIDM00184	Melanoma	GDSC	ATSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1111
p.V1206M	SIDM00544	Neuroblastoma	GDSC	VDSSS	DEG_SPOP_SBC_1	1206:1210	Mutation altering degron motif	0.7208
p.V1206M	SIDM00463	T-Lymphoblastic Leukemia	GDSC	VDSSS	DEG_SPOP_SBC_1	1206:1210	Mutation altering degron motif	0.7208
p.V1206M	SIDM01005	Acute Myeloid Leukemia	GDSC	VDSSS	DEG_SPOP_SBC_1	1206:1210	Mutation altering degron motif	0.7208
p.V1206M	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	VDSSS	DEG_SPOP_SBC_1	1206:1210	Mutation altering degron motif	0.7208
p.V1206M	SIDM01180	Hepatocellular Carcinoma	GDSC	VDSSS	DEG_SPOP_SBC_1	1206:1210	Mutation altering degron motif	0.7208
p.V1206M	SIDM00016	Neuroblastoma	GDSC	VDSSS	DEG_SPOP_SBC_1	1206:1210	Mutation altering degron motif	0.7208
p.V1206M	SIDM01434	Hepatocellular Carcinoma	GDSC	VDSSS	DEG_SPOP_SBC_1	1206:1210	Mutation altering degron motif	0.7208
p.A1165V	SIDM00846	Cervical Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	1165:1169	Mutation altering degron motif	0.5825
p.A1165V	SIDM00210	Ovarian Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	1165:1169	Mutation altering degron motif	0.5825
p.A1165V	SIDM00673	Breast Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	1165:1169	Mutation altering degron motif	0.5825
p.A1165V	SIDM00785	Acute Myeloid Leukemia	GDSC	AKSSS	DEG_SPOP_SBC_1	1165:1169	Mutation altering degron motif	0.5825
p.A1165V	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	1165:1169	Mutation altering degron motif	0.5825
p.A1165V	SIDM01763	Rhabdomyosarcoma	GDSC	AKSSS	DEG_SPOP_SBC_1	1165:1169	Mutation altering degron motif	0.5825
p.E1444D	SIDM00945	Colorectal Carcinoma	GDSC	EKENV	DEG_APCC_KENBOX_2	1450:1454	Mutation rewiring degron network	0.1667
p.S544A	SIDM01259	B-Lymphoblastic Leukemia	GDSC	ATSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.3056
p.A554G	SIDM00889	Cervical Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1944
p.A1211P	SIDM01097	Other Solid Cancers	GDSC	VDSSS	DEG_SPOP_SBC_1	1206:1210	Mutation rewiring degron network	0.3056
p.P1173L	SIDM00333	Endometrial Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	1165:1169	Mutation rewiring degron network	0.2222
p.S300F	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	LVMTPDPE	DEG_SCF_FBW7_2	301:308	Mutation rewiring degron network	0.3056
p.S1097C	SIDM00870	Breast Carcinoma	GDSC	PVSTS	DEG_SPOP_SBC_1	1095:1099	Mutation altering degron motif	0.7541
p.R1103Q	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVSTS	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TASOR2

UniProt ID: Q5VWN6

Entrez ID: 54906

Protein name: Protein TASOR 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TASOR2 in