DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LVMTPDPE
Uniprot ID:
Q5VWN6
Source protein:
Protein TASOR 2
Source gene:
TASOR2
Class:
DEG_SCF_FBW7_2
Location:
301:308
E3 ligase:
FBXW7
DEGRON score:
0.9181
ASA_SCORE:
77.7875
COIL:
0.7356
CONS_SCORE:
0.7862
DSS_SCORE:
0.3115
HELIX:
0.1894
FCONS_SCORE:
1.1442
RIG_SCORE:
0.773
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S300F
SIDM00737
Non-Small Cell Lung Carcinoma
GDSC
LVMTPDPE
DEG_SCF_FBW7_2
0.3056
Drug responses associated with TASOR2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LVMTPDPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5VWN6
Protein TASOR 2
DEG_SCF_FBW7_2
301:308
LVMTPDPE
FBXW7
0.9181
More...