DegronMD

Uniprot ID: Q5VVP1

Source protein: Spermatogenesis-associated protein 31A6

Source gene: SPATA31A6

Class: LIG_APCC_ABBA_1

Location: 105:110

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.994

ASA_SCORE: 79

COIL: 0.8613

CONS_SCORE: 0.4053

DSS_SCORE: 0.5696

HELIX: 0.0902

FCONS_SCORE: 1.1731

RIG_SCORE: 0.6705

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S95L	TCGA-32-4210	GBM	TCGA	LGPHLD	LIG_APCC_ABBA_1	0.0556
p.S95L	TCGA-74-6581	GBM	TCGA	LGPHLD	LIG_APCC_ABBA_1	0.0556
p.S95L	TCGA-EE-A2MD	SKCM	TCGA	LGPHLD	LIG_APCC_ABBA_1	0.0556
p.S95L	DO11645	GBM	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.0556
p.S95L	DO11531	GBM	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.0556
p.S95L	DO222434	MELA	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.0556
p.S95L	DO37851	SKCM	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.0556
p.L98R	TCGA-AJ-A3EK	UCEC	TCGA	LGPHLD	LIG_APCC_ABBA_1	0.1389
p.L98R	DO41584	UCEC	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.1389
p.P107S	TCGA-AM-5821	COAD	TCGA	LGPHLD	LIG_APCC_ABBA_1	0.6752
p.P107S	DO8240	COAD	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.6752
p.D96H	DO229056	LICA	ICGC	LGPHLD	LIG_APCC_ABBA_1	0.0833
p.D96E	SIDM00482	Chronic Myelogenous Leukemia	GDSC	LGPHLD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TZJ5	Spermatogenesis-associated protein 31A1	LIG_APCC_ABBA_1	105:110	LGPHLD	APC,CDC20,FZR1	0.9874	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	LIG_APCC_ABBA_1	105:110	LGPHLD	APC,CDC20,FZR1	0.8604	More...
Q5VU36	Spermatogenesis-associated protein 31A5	LIG_APCC_ABBA_1	105:110	LGPHLD	APC,CDC20,FZR1	0.8887	More...
Q5VVP1	Spermatogenesis-associated protein 31A6	LIG_APCC_ABBA_1	105:110	LGPHLD	APC,CDC20,FZR1	0.994	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	LIG_APCC_ABBA_1	105:110	LGPHLD	APC,CDC20,FZR1	0.9544	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons