DegronMD

Uniprot ID: Q5VYP0

Source protein: Spermatogenesis-associated protein 31A3

Source gene: SPATA31A3

Class: DEG_Kelch_Keap1_1

Location: 646:651

E3 ligase: KEAP1

DEGRON score: 0.8689

ASA_SCORE: 78.2333

COIL: 0.854

CONS_SCORE: 0.4285

DSS_SCORE: 0.714

HELIX: 0.0953

FCONS_SCORE: 0.9875

RIG_SCORE: 0.5647

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S652I	TCGA-EO-A3AY	UCEC	TCGA	SMSTGE	DEG_Kelch_Keap1_1	0.3056
p.S652I	DO43202	UCEC	ICGC	SMSTGE	DEG_Kelch_Keap1_1	0.3056
p.W643L	DO228976	LICA	ICGC	SMSTGE	DEG_Kelch_Keap1_1	0.25
p.V659A	SIDM01314	Colorectal Carcinoma	GDSC	SMSTGE	DEG_Kelch_Keap1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TZJ5	Spermatogenesis-associated protein 31A1	DEG_Kelch_Keap1_1	646:651	SMSTGE	KEAP1	0.739	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_Kelch_Keap1_1	646:651	SMSTGE	KEAP1	0.548	More...
Q5VYP0	Spermatogenesis-associated protein 31A3	DEG_Kelch_Keap1_1	646:651	SMSTGE	KEAP1	0.8689	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons