DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SMSTGE
Uniprot ID:
Q5VU36
Source protein:
Spermatogenesis-associated protein 31A5
Source gene:
SPATA31A5
Class:
DEG_Kelch_Keap1_1
Location:
646:651
E3 ligase:
KEAP1
DEGRON score:
0.548
ASA_SCORE:
76.7667
COIL:
0.8568
CONS_SCORE:
0.4204
DSS_SCORE:
0.7183
HELIX:
0.0835
FCONS_SCORE:
0.9839
RIG_SCORE:
0.5625
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SPATA31A5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SMSTGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5TZJ5
Spermatogenesis-associated protein 31A1
DEG_Kelch_Keap1_1
646:651
SMSTGE
KEAP1
0.739
More...
Q5VU36
Spermatogenesis-associated protein 31A5
DEG_Kelch_Keap1_1
646:651
SMSTGE
KEAP1
0.548
More...
Q5VYP0
Spermatogenesis-associated protein 31A3
DEG_Kelch_Keap1_1
646:651
SMSTGE
KEAP1
0.8689
More...