DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SMSTGE
Uniprot ID:
Q5TZJ5
Source protein:
Spermatogenesis-associated protein 31A1
Source gene:
SPATA31A1
Class:
DEG_Kelch_Keap1_1
Location:
646:651
E3 ligase:
KEAP1
DEGRON score:
0.739
ASA_SCORE:
80.15
COIL:
0.841
CONS_SCORE:
0.3321
DSS_SCORE:
0.7091
HELIX:
0.1033
FCONS_SCORE:
0.8822
RIG_SCORE:
0.5662
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SPATA31A1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SMSTGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5TZJ5
Spermatogenesis-associated protein 31A1
DEG_Kelch_Keap1_1
646:651
SMSTGE
KEAP1
0.739
More...
Q5VU36
Spermatogenesis-associated protein 31A5
DEG_Kelch_Keap1_1
646:651
SMSTGE
KEAP1
0.548
More...
Q5VYP0
Spermatogenesis-associated protein 31A3
DEG_Kelch_Keap1_1
646:651
SMSTGE
KEAP1
0.8689
More...